نتایج جستجو برای: morphine sensitization

تعداد نتایج: 32486  

2011
Gary B. Kaplan Kimberly A. Leite-Morris WenYing Fan Angela J. Young Marsha D. Guy

Sensitization to the effects of drugs of abuse and associated stimuli contributes to drug craving, compulsive drug use, and relapse in addiction. Repeated opiate exposure produces behavioral sensitization that is hypothesized to result from neural plasticity in specific limbic, striatal and cortical systems. ΔFosB and FosB are members of the Fos family of transcription factors that are implicat...

Journal: :فصلنامه علمی پژوهشی گیاهان دارویی 0
a haghparast neuroscience research center shahid beheshti university, m.c. p.o.box: 19615-1178, tehran, iran tel & fax: +98-21-22431624 j zarringhalam neuroscience research center, shahid beheshti university of medical sciences, tehran a khatibi neuroscience research center, shahid beheshti university of medical sciences, tehran e dianati neuroscience research center, shahid beheshti university of medical sciences, tehran j shams neuroscience research center, shahid beheshti university of medical sciences, tehran

background: cuminum cyminum fruit essential oil (feo) dose-dependently can attenuate the expression of morphine tolerance and dependence in morphine-dependent mice. objective: in this study, the effects of cuminum cyminum feo on acquisition and expression of morphine-induced conditioned place preference (cpp) in morphine-sensitized mice were studied. methods: repeated subcutaneous (s.c.) admini...

Journal: :Behavioural brain research 2010
Thomas I Nathaniel Jaak Panksepp Robert Huber

Recent neuroethological work suggests that drug-sensitive reward in Crayfish represents a useful new model system for the study of drug dependence. Monoamine re-uptake mechanisms, which are conserved across vertebrate and invertebrate taxa, offer sites of action for testing drug-induced behavioral sensitization. The present study explored drug-associated behavioral sensitization in Crayfish by ...

Journal: :The Journal of pharmacology and experimental therapeutics 2004
Kimberly A Leite-Morris Eugene Y Fukudome Marwa H Shoeb Gary B Kaplan

Opiate-induced motor sensitization refers to the progressive and enduring motor response that develops after intermittent drug administration, and results from neuroadaptive changes in ventral tegmental area (VTA) and nucleus accumbens (NAc) neurons. Repeated activation of mu-opioid receptors localized on gamma-aminobutyric acid (GABA) neurons in the VTA enhances dopaminergic cell activity and ...

2014
Shamseddin Ahmadi Shaho Azarian Sayede Shohre Ebrahimi Ameneh Rezayof

INTRODUCTION We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. METHODS We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior test ...

2016
Amir Arash Motahari Hedayat Sahraei Gholam Hossein Meftahi

The catastrophic effects of opioids use on public health and the economy are documented clearly in numerous studies. Repeated morphine administration can lead to either a decrease (tolerance) or an increase (sensitization) in its behavioral and rewarding effects. Morphine-induced sensitization is a major problem and plays an important role in abuse of the opioid drugs. Studies reported that mor...

Journal: :Drug and alcohol dependence 2011
Shiou-Lan Chen Kuei-Ying Hsu Eagle Yi-Kung Huang Ru-Band Lu Pao-Luh Tao

Chronic use of morphine causes rewarding and behavioral sensitization, which may lead to the development of psychological craving. In our previous study, we found that a widely used antitussive dextromethorphan (known as a low affinity NMDA receptor antagonist), at doses of 10-20 mg/kg (i.p.), effectively decreased morphine rewarding in rats. In this study, we further investigated the effects a...

Journal: :The international journal of neuropsychopharmacology 2011
Juan Luo Li Jing Wang-Jun Qin Min Zhang Andrew J Lawrence Feng Chen Jian-Hui Liang

New protein synthesis has been implicated as necessary for long-lasting changes in neuronal function. Behavioural sensitization to a single exposure to addictive drugs is a form of neuroplasticity, but little is known about the importance of new protein synthesis in the underlying mechanism. This study was designed to investigate the effects of the transcription inhibitor actinomycin D (AD) and...

Journal: :European journal of pharmacology 2012
Maryam Farahmandfar Nasser Naghdi Seyed Morteza Karimian Mehdi Kadivar Mohammad-Reza Zarrindast

The present study investigated the effect of morphine sensitization on the impairment of spatial memory retrieval induced by acute morphine in adult male rats. Spatial memory was assessed by 2-day Morris water maze task which included training and test day. On the training day, rats were trained by a single training session of 8 trials. On the test day, a probe trial consisting of 60s free swim...

2014
Marzieh Molaei Mohammad-Hossein Sanati Jalal Zaringhalam Abbas Haghparast

INTRODUCTION Previous studies have shown that the basolateral amygdale (BLA) is rich of CB1 cannabinoid receptors and involved in cannabinoid-induced antinociception. Also, it seems that there are functional interactions between the cannabinoid CB1 and opioid receptors in the process of sensitization to opiates. In the present study, we tried to examine the role of intra-BLA cannabinoid recepto...

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