Results After 28 days the use of GB and 20 days of grafting, she had morbilliform rash, fever (39C), cervical and inguinal adenopathy. CBC was performed: hemoglobin 10,3g/dl, leukocyte 14,900/mm3, neutrophils 58.9%, eosinophils 16.4% (2,443), lymphocytes 10% and monocytes 3.1%. Platelets were normal. ALT 200 U/L (up to 55), AST 180U/L (up to 34), creatinine 1.8 mg/dl (up to 1). Previous examina...

Fourteen patients of approximately 5,000 taking PAS imi this institution acquired a severe hypersensitivity to the drug. The reaction began 15 to 43 days after the beginning of therapy and all cases developed fever (100.2 to 105#{176} F.), rash and pruritus (table 1). The rash involved the face, neck, and extremities in the milder cases and was generalized in the severer ones. Usually it was er...

West Nile Virus (WNV) is a leading cause of viral encephalitis in the United States. Infected mosquitos deliver virus to skin before moves draining lymph nodes establish systemic infection. In vitro studies human keratinocytes and vivo mice suggest role for replication, rashes have been reported half WNV patients, but early stages infection patients remain incompletely understood. We report 58-...

BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening acute drug-induced hypersensitivity reaction. Antiepileptic drugs (AEDs) predominantly aromatic AEDs are commonly reported in DRESS. To date there are no reports of sulthiame AED causing DRESS syndrome. METHOD We report a 10-year-old girl of Indian descent with AED resi...

TO THE EDITOR—Based on old medical reports, it is commonly accepted that the acute phase of Epstein-Barr virus (EBV) infection (henceforth called “AEI”) induces a transient hypersensitivity to β-lactams, resulting in a rash in up to 90%–100% of patients inadvertently given penicillin derivatives (PDs) [1–3]. As a result, such a drug-induced reaction has become suggestive of EBV primary infectio...

A 7-year-old boy with flu-like symptoms treated with amoxicillin presented with cervical lymphadenopathy; maculopapular rash on arms, face, and trunk; and markedly high white blood cell (WBC) count (100 3 10 9 /L) and high absolute lymphocyte count (85 3 10 9 /L). The peripheral smear revealed a heterogeneous population of lymphocytes (panels A and B). Howell-Jolly bodies were also seen (panel ...

Background: Although most cases of drug eruptions are mildand self-limited and are relieved after discontinuation of theresponsible drugs, statistics of life threatening outcomes shouldbe kept in mind. Moreover, it is important to identify the mostcommon age and sex groups, and the most vulnerable groupsin any area related to offending drugs. Thus, we collected thebasic information of patients ...

Dapsone (4,4'-diaminodiphenylsulfone, DDS), a potent anti-inflammatory agent, is widely used in the treatment of leprosy and several chronic inflammatory skin diseases. Dapsone therapy rarely results in development of dapsone hypersensitivity syndrome, which is characterized by fever, hepatitis, generalized exfoliative dermatitis, and lymphadenopathy. Here, we describe the case of an 11-year-ol...

BACKGROUND Dengue is a mosquito-borne viral infection endemic throughout the tropics and subtropics. The global prevalence of dengue has grown dramatically in recent years and it has been recognized as a potential hazard to tourists. OBJECTIVE In this study, we analyzed the epidemiology, clinical manifestations, laboratory features and serological/virological results in a series of German tra...