BACKGROUND AND PURPOSE Zonisamide (ZNS) is a useful antiepileptic drug with a broad therapeutic spectrum. However, there is limited information on the long-term use of ZNS as a monotherapy. This study investigated the long-term effects of ZNS as a monotherapy for the treatment of epilepsy. METHODS We retrospectively analyzed the records of epilepsy patients treated with ZNS monotherapy at our...

conclusions these findings indicate that telbivudine, used in both monotherapy and combination therapy, improves the renal function of patients with chb. the improvements are particularly significant in patients at high renal risk. patients and methods this study included 336 chinese chb patients, who were selected from outpatients in tongji hospital. 44, 122, 66, 58, and 46 of these patients h...

Is there a place for monotherapy? Yes, there is a place for monotherapy. According to the Seventh report of the Joint National Committee in 2003 (1) and the European guidelines from 2007 (2) and 2009 (3), the first step in hypertension control is changing lifestyle before initiating medical treatment. According to the baseline blood pressure and the presence or absence of target organ damage an...

BACKGROUND To determine the cost-effectiveness of strategies of preferred antibiotic treatment with beta-lactam/macrolide combination or fluoroquinolone monotherapy compared to beta-lactam monotherapy. METHODS Costs and effects were estimated using data from a cluster-randomized cross-over trial of antibiotic treatment strategies, primarily from the reduced third payer perspective (i.e. hospi...

BACKGROUND Real-life registry data reveal approximately one-third of patients taking biologic agents use them as monotherapy, in spite that combination therapy with Disease Modifying Drugs is more efficacious than monotherapy. The aim of our study was to assess the prevalence of biologics monotherapy in a cohort of patients with RA followed at a single center, and to analyze the reasons for mon...

OBJECTIVE A randomized, parallel-group, open-label, multicenter 16-week clinical trial compared efficacy and safety of repaglinide monotherapy and nateglinide monotherapy in type 2 diabetic patients previously treated with diet and exercise. RESEARCH DESIGN AND METHODS Enrolled patients (n = 150) had received treatment with diet and exercise in the previous 3 months with HbA(1c) >7 and < or =...

CONTEXT The safety of insulin in the treatment of type 2 diabetes mellitus (T2DM) has recently undergone scrutiny. OBJECTIVE The objective of the study was to characterize the risk of adverse events associated with glucose-lowering therapies in people with T2DM. DESIGN AND SETTING This was a retrospective cohort study using data from the UK General Practice Research Database, 2000-2010. P...

PURPOSE Antipsychotic monotherapy is often recommended over antipsychotic polypharmacy because of fewer adverse events, reduced treatment complexity, and lower medication cost. This study compared the rate and the duration of antipsychotic monotherapy following initiation of olanzapine or risperidone in the treatment of outpatients with schizophrenia in Japan. METHODS Outpatients diagnosed wi...

INTRODUCTION The aim of this study was to describe factors associated with initiating a biologic as monotherapy vs in combination with a conventional disease-modifying antirheumatic drug (DMARD) in biologic-naive patients with rheumatoid arthritis (RA) enrolled in the Corrona registry. METHODS First biologic initiations were classified as monotherapy (Bio MT) or combination therapy (Bio CMB)....

OBJECTIVE Evaluate the efficacy of L-methylfolate in combination with SSRI or SNRI compared to SSRI or SNRI monotherapy in a major depressive episode. DESIGN A retrospective analysis of L-methylfolate plus SSRI/SNRI at treatment initiation (n=95) and SSRI/SNRI monotherapy (n=147) from patient charts. SETTING Outpatient, private psychiatric clinic/practice. PARTICIPANTS Adults 18 to 70 wit...