Introduction: Studies have shown that insufficient recovery between sessions causes immune suppression. The aim of this study was to investigate the effect of repeated bouts resistance and endurance exercise on blood leukocytes, lymphocytes, neutrophils, monocytes count and plasma cortisol levels in athlete girls. Materials and methods: 9 athlete girls (ages, 20-25 years), participated i...

This study examined the adhesive interaction of peripheral blood monocytes with VCAM-1 and analyzed the effect of P-selectin binding to monocytes on the adhesive interaction with VCAM-1 under flow conditions. P-selectin glycoprotein ligand-1 is expressed on most monocytes. Furthermore, most monocytes bind soluble P-selectin derived from platelets. P-selectin binding to monocytes did not alter t...

Recent studies have implicated monocytes/macrophages play important roles in the pathogenesis of systemic sclerosis (SSc). We previously reported levels circulating periostin were increased SSc, and it was positively correlated with modified Rodnan's total skin thickness score (mRSS). Therefore, we focused on effect monocytes monocyte-derived macrophages (MDM) SSc. Monocytes purified from blood...

the exact developmental origin of microglia is still under debate. in the present study we investigated which heamatopoietic tissues and which features of the organotypic brain slice culture promoted microglia ramification. the potential of cells derived from embryonic yolk sac, embryonic aorta-gonad-mesonephros and adult blood monocytes was examined. these tissues were co-cultured with brain s...

Abstract Accumulating data have highlighted the role of monocytes/macrophages in immune escape by generating immunologically “cold” tumors that do not respond to immunotherapy. CD244 (SLAMF4, 2B4), a member signaling lymphocyte activation molecule family, is expressed on myeloid cells, but its precise has been elucidated. Using monocyte lineage-specific CD244-deficient micechallenged with B16F1...

Abstract Certain proinflammatory stimuli can metabolically and epigenetically modify monocytes/macrophages or NK cells to be more responsive secondary stimuli, a process known as trained innate immunity. However, the longevity of immunity is unclear. In this study, we report that Fasciola hepatica excretory-secretory products (FHES) imprint an anti-inflammatory phenotype on long-term hematopoie...

The presence of several different autoantibodies (auto-AT) at the same time is a specific peculiarity “autoantibody profile” SLE (systemic lupus erythematosus). It known that induction auto-AT formation involves both nonspecific and antigen-specific immunoregulatory disorders. In apoptosis, primary changes in cell membrane composition or/and excretion intracellular compounds into intercellular ...

Low levels of CD2 have been described on subsets of monocytes, macrophages, and dendritic cells. CD2 is expressed on about one-third of circulating monocytes, at levels one-half log lower than on T or NK cells, representing 2-4% of PBMC. FACS analysis of CD2+ and CD2- monocytes revealed no significant difference in the expression of adhesion molecules (CD11a/b/c), class II Ags (HLA-DR, -DQ, -DP...

OBJECTIVE To investigate the effect of HIV Tat protein on Bcl-2 expression in human monocytes, and observe apoptosis of Tat-stimulated monocytes induced by TNF-alpha-related apoptosis-induced ligand (TRAIL). METHODS Western blot was used to detect Bcl-2 expression in monocytes stimulated by HIV Tat protein, and Annexin V and 7-AAD staining were used to detect apoptosis of monocytes induced by...