p-Chloroamphetamine (PCA) causes a rapid and long-lasting depletion of serotonin in rat brain [l]. PCA is thought to affect serotonin neurons acutely by (a) inhibition of tryptophan hydroxylation, (b) release of vesicular bound serotonin, (c) inhibition of serotonin reuptake from the synaptic cleft, and (d) inhibition of serotonin oxidation by monoamine oxidase, and to produce neurotoxic degene...

3-(3,4-Dichlorophenyl)-5-(1H-indol-5-yl)-1,2,4-oxadiazole was synthesized via the condensation of 3,4-dichlorobenzamidoxime and methyl 1H-indole-5-carboxylate using a superbasic medium (NaOH/DMSO). The compound tested as potential inhibitor human monoamine oxidase (MAO) A B. It demonstrated notable inhibition with an IC50 value 0.036 μM for MAO-B isoform specificity. product characterized by 1H...

Inhibitions of the relatively highly purified flavoenzyme, bovine kidney mitochondrial monoamine oxidase, previously described in Paper I (Erwin, V. G., and Hellerman, L., J. Biol. Gem., 242, 4230 (1967)), by several agents of current interest have been investigated. The inhibitors include Nmethyl-N-(Z-propynyl)benzylamine (pargyline), (+)-fransphenylcyclopropylamine (d form of tranylcypromine)...

Biochemical and pharmacological investigations about the effect of the antidepressant drug viloxazine (Vivalan) on catecholamine metabolism in rats led to the following results: Viloxazine exerts a dose and time dependent inhibition of monoamine oxidase activity of brain and liver mitochondrial fraction and tissue homogenates of hypothalamus, heart, liver, and adrenal glands, both in vitro and ...

microcantilevers (mcls) are cost-effective and highly sensitive devices for biodetection. adsorption of specific analytes on the microcantilever surface causes the bending of mcl through changing of the surface characteristics. these new bioprobes designed in a way that one side of the microcantilever surface is coated with a selective receptor that absorbs particular molecules. after surface a...

The goal of this brief review is to explain the role of monoamine oxidase enzymes in the neurobiology, etiology, and presentation of psychiatric illnesses, primarily major depressive disorder. This article will initially focus on the basic science and function of the monoamine oxidase system and some proposed neuropsychiatric symptoms that may arise if this enzyme system is altered by genetic p...

To develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the HPLC method and a new substrate was used to develop a peroxidase-linked spectrophotometric assay. 4-(Trifluoromethyl) benzylamine (11) was proved to be an exc...