drug clorgyline. Type B enzyme (or enzymes) deaminates only dopamine and is inhibited by deprenyl. The clinical papers include presentations and discussion by pioneers in the use of monoamine oxidase inhibitors in clinical states. Pare's observation that some bipolar depressions respond only to monoamine oxidase inhibitors is in accord with some clinical observations made at Yale by Himmelhoch ...

The aim of the present work was to determine whether the increase in monoamine oxidase activity previously found in hyperand hypothyroid rats, was due to thyroxin effects on enzymatic activity or to variations in enzyme synthesis. The rate of synthesis of monoamine oxidase in young hyperand hypothyroid rats has been studied by measuring the recovery of enzymatic activity 7 days after irreversib...

Dose-response curves of pupillary dilation after topical administration of norepinephrine or methoxamine have been determined in rabbits after chronic inhibition of ocular monoamine oxidase by treatment with pargyline or pheniprazine. Eyes treated with either monoamine oxidase inhibitor showed an enhanced responsiveness to the mydriatic effect of norepinephrine given either topically or intrave...

Monoamine oxidase B catalytically oxidizes biogenic amines such as phenylethylamine and dopamine, and its activity is presumed to be related to particular behavioral traits. In this study, we first identified a single nucleotide polymorphism (T199C) located on the putative third exon of the canine monoamine oxidase B gene, which causes an amino acid substitution from cysteine to arginine. We th...

Increased plasma histamine levels were associated with significantly lowered diamine and type B monoamine oxidase activities in platelet-rich plasma of atopic eczema (AE) patients. The diamine oxidase has almost normal cofactor levels (pyridoxal phosphate and Cu(2+)) but the cofactor levels for type B monoamine oxidase (flavin adenine dinucleotide and Fe(2+)) are lowered. The biogenic amines pu...

Mean platelet monoamine oxidase activity was reduced compared with control values in groups of headache-free male (but not female) patients suffering from classical migraine and from tension headache. Mean activity in male cluster patients, headache free, both during acute and quiescent phases of their illness, was also notably reduced. Retesting some migraine subjects after up to four years, s...