....................................................................... 10 1. REVIEW OF THE LITERATURE ........................................ 11 1.1 RET RECEPTOR TYROSINE KINASE.................................. 11 1.1.1 RET gene and RET proteins............................................. 11 1.1.2 RET is a functional receptor for GDNF-family ligands (GFLs).... 12 1.1.3 RET-dependent GFLs si...

Molecular rotors have emerged as versatile probes for microscopic viscosity in live cells, however, the exclusive localisation of rotors in the plasma membrane has remained elusive. We report the synthesis, spectroscopic characterisation and live cell imaging of a new BODIPY-based molecular rotor suitable for mapping viscosity in the cell plasma membrane.

Paul Curley1, Neill J Liptrott1,2 & Andrew Owen*,1,2 1Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK 2European Nanomedicine Characterisation Laboratory, Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK * Author for correspondence: Tel.: +44 0 ...