The asymmetric unit of the title compound, C(9)H(9)N(3)O(2)S(2), contains two independent mol-ecules, A and B, with similar bond dimensions. In both mol-ecules, the nitro group is tilted with respect to the aromatic ring [dihedral angles 32.0 (1)° in mol-ecule A and 34.0 (1)° in mol-ecule B]. The dithio-carbazate unit is nearly coplanar with the aromatic ring in both mol-ecules. For mol-ecule B...

Current colorectal cancer (CRC) treatments exhibit unwanted cytotoxicity against healthy proliferating cells. Hence, these therapeutics demand higher specificity upon drug delivery, a task that may be facilitated by the discovery of anticancer agents bearing critical mechanisms action. Baicalein is flavonoid with promising activity, among other pharmacological benefits, and has therefore been h...

We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aort...

The title compound, C(20)H(16)N(4)O(4), contains two crystallographically independent mol-ecules (A and B) in the asymmetric unit. Intra-molecular N-H⋯O hydrogen bonds generate S(6) ring motifs in both molecules. The dihedral angles between the nitro-substituted benzene rings and the two benzene rings in mol-ecules A and B are 14.32 (9), 17.89 (9)° and 13.04 (9) and 25.71 (9)°. The ortho and pa...

The sulfa-thia-zole mol-ecule in the title 1:1 co-crystal, C9H9N3O2S2·C18H12N6, adopts an approximate L-shape [dihedral angle between the five- and six-membered rings = 86.20 (9)°] and features an intra-molecular hypervalent S⋯O inter-action [2.8666 (15) Å]. Overall, the triazine mol-ecule has the shape of a disk as the pendant pyridine rings are relatively close to coplanar with the central ri...

1 Investigation of cooperativity in the binding of ligands to the D 2 dopamine receptor. Abstract The D 2 dopamine receptor exists as dimers or as higher order oligomers, based on data from physical experiments. In this study we have sought evidence that this oligomerisation leads to cooperativity by examining the binding of three radioligands ([ 3 H]nemonapride, [ 3 H]raclopride, [ 3 H]spipero...

acrjourna understanding of the anatomy and development of fetal and adult hair follicles and the molecular of the major embryonic pathways that regulate the hair follicle have led to exciting discoveries rning the development of basal cell carcinoma (BCC). These studies have shed light on the major f Sonic hedgehog (Shh) signaling and its interactions with the insulin-like growth factor (IGF) a...

In the crystal of the title compound, C19H14N4O4, the asymmetric unit consists of two discrete mol-ecules. The C=N bonds in both mol-ecules show an E conformation. The dihedral angles between the C atoms of the 2,4-dinitrobenzene rings and the C=N-N planes are 13.52 (9) and 13.82 (9)° for the two mol-ecules. In the crystal, C-H⋯O hydrogen bonds, mainly between the phenyl ring and the nitro grou...