Corticosteroids are currently the first line of treatment for patients with atopic dermatitis. In the pediatric population however, the potential impact of adrenal suppression is always an important safety concern. Twenty boys and girls, 5-12 years of age, with normal adrenal function and a history of atopic dermatitis were maximally treated three times daily with a lipid-rich, moisturizing for...

Epidermal filaggrin level is affected by ultraviolet B irradiation in animal and experimental models. This study examined the effect of ultraviolet B irradiation on epidermal filaggrin and natural moisturizing factors in vivo in healthy adults (n = 22). Participants were irradiated with 2 minimal erythema doses of ultraviolet B on the skin. Biopsies and tape strips were collected from skin irra...

Itch is frequently associated with dermatoses characterized by a defective skin barrier. We formulated an itch-relieving moisturizing cream containing 3% menthol and ceramides. Our aim was to evaluate the safety and antipruritic efficacy of application of this cream in volunteers with and without skin diseases. Volunteers were asked to apply the cream for 1 month on a minimum body surface area ...

The utilization of cosmetic raw materials for medicinal purposes in a microneedle patch containing hyaluronic acid (HA) and Lonicerae flos ethanol extract (LEE) has increased based on their eco-friendly characteristics. moisturizing effects this were assessed the forearms 20 female participants, our results showed an increase between 29.60% 88.54% skin moisture content at same time points relat...

BACKGROUND An outbreak of severe nosocomial Burkholderia cepacia infections in patients admitted to intensive care unit (ICU), including investigation of the reservoir, is described. METHODS Over a period of 18 days, isolates of Burkholderia cepacia were recovered from different biological samples from five patients who were admitted to a multidisciplinary 18-bed intensive care unit. Isolatio...

Aloe vera is an herb distributed throughout the world. The herb is used internally to combat most digestive problems, including constipation, poor appetite, colitis, irritable bowel syndrome as well as, asthma, diabetes, immune system enhancement, peptic ulcers. A scrutiny of literature revealed some notable pharmacological activities of the plant such as anti-inflammatory, antiviral and antitu...

OBJECTIVES In the current study, sunscreen and moisturizing properties of solid lipid nanoparticle (SLN)-safranal formulations were evaluated. MATERIALS AND METHODS Series of SLN were prepared using glyceryl monostearate, Tween 80 and different amounts of safranal by high shear homogenization, and ultrasound and high-pressure homogenization (HPH) methods. SLN formulations were characterized f...