a gel composite (based on polyacrylamide and crosslinker cr(iii) acetate) was prepared by solvent method (distillate and water formation) and nanoclay particle (kaolinite). using xrd tests, d001 was evaluated for kaolinite nanoparticles in gel composite. kaolinite modification using dimethyl-sulfoxide led to increase interlamellar spacing from 7.21 to 10.82 o a. based on the results obtained fo...

Biodistribution of nanoparticle-based intracellular delivery systems is mediated primarily by particle size and physicochemical properties. As such, overcoming the rapid removal of these by the reticuloendothelial system remains a significant challenge. To date, a number of copolymer nanoparticle systems based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl meth...

Paclitaxel-polylactide (Ptxl-PLA) conjugate nanoparticles, termed as nanoconjugates (NCs), were prepared through Ptxl/(BDI)ZnN(TMS)(2) (BDI = 2-((2,6-diisopropylphenyl)-amido)-4-((2,6-diisopropylphenyl)-imino)-2-pentene)-mediated controlled polymerization of lactide (LA) followed by nanoprecipitation. Nanoprecipitation of Ptxl-PLA resulted in sub-100 nm NCs with monomodal particle distributions...

We demonstrated a one-pot, soap-free fabrication of porous polycaprolactone microspheres by combining nanoprecipitation and hydrolysis. The obtained porous polycaprolactone microspheres show great advantages for application in drug delivery.

The purpose of this study was to develop the surface modification of docetaxel nanocrystals (DTX-NCs) with apo-Transferrin human (Tf) for improving the cellular uptake and cytotoxicity of DTX. DTX-NCs were prepared by a nanoprecipitation method, and the surface modified with Tf by an adsorption method (Tf-DTX-NCs). The morphology and particle size of DTX-NCs and Tf-DTX-NCs were characterized us...

These methods describe how to formulate injectable, supramolecular polymer-nanoparticle (PNP) hydrogels for use as biomaterials. PNP are composed of two components: hydrophobically modified cellulose the network polymer and self-assembled core-shell nanoparticles that act non-covalent cross linkers through dynamic, multivalent interactions. both formation these nanoprecipitation well formulatio...

A model study has been conducted for Flash Nanoprecipitation (FNP)sa novel approach to produce functional nanoparticles. A population balance equation with the FNP kinetics has been integrated into a computational fluid dynamics (CFD) simulation of a custom-designed microscale multi-inlet vortex reactor (MIVR) to yield conditions comparable to the real experimental settings. In coping with the ...