Neurodegeneration 99 Defi ning SOD1 ALS natural history to guide therapeutic clinical trial design T Bali, W Self, J Liu, T Siddique, L H Wang, T D Bird, E Ratti, N Atassi, K B Boylan, J D Glass, N J Maragakis, J B Caress, L F McCluskey, S H Appel, J P Wymer, S Gibson, L Zinman, T Mozaffar, B Callaghan, A L McVey, J Jockel-Balsarotti, P Allred, E R Fisher, G Lopate, A Pestronk, M E Cudkowicz, T...

BACKGROUND Overexpression of epidermal growth factor receptor (EGFR) is found in many types of neoplasms. The aim of the study was to evaluate EGFR expression in colorectal cancer (CRC) specimens and to determine whether EGFR expression correlates with clinicopathological data and overall survival. PATIENTS AND METHODS Tissue specimens from 181 consecutive CRC patients treated at the Military...

The digital gates are basic electronic component of any digital circuit. Digital circuit should be simplified in order to reduce its cost by reducing number of digital gates required to implement it. To achieve this, we use Boolean expression that helps in obtaining minimum number of terms and does not contain any redundant pair. Karnaugh map (K-map) and Quine-McCluskey (QM) methods are well kn...

In 1993, breast cancer will likely be diagnosed in more than 150000 women in the United States. In that group, those with axillary lymph node-negative (ANN) disease present one of the greatest dilemmas facing oncologists today. In this issue of the Journal, an article by Allred et al. (7) exemplifies an important trend in the search for a resolution to this problem—the use of this type of progn...

Estrogen receptor (ER) cx, a splice variant of ER , is a dominant repressor of ER function. In this study we investigated the possibility that because the progesterone receptor (PR) gene is a downstream target of activated ER , in ER -positive breast cancers, expression of ER cx would result in repression of PR. In ER -positive MCF-7 cells, stable transfection of an ER cx expression vector resu...

a relationship based on the modified couple stress theory is developed to investigate the flexural sensitivity of an atomic force microscope (afm) with assembled cantilever probe (acp). this acp comprises a horizontal cantilever, two vertical extensions and two tips located at the free ends of the extensions which form a caliper. an approximate solution to the flexural vibration problem is obta...

Food allergies are recognized as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well-known foods and foods containing genetically modified ingredients is installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods, including novel sources, not yet used for human consum...