Healing of corneal alkali injuries remains a severe clinical challenge. The authors evaluated the effect of a new synthetic inhibitor of matrix metalloproteinases (GM6001 or N-[2(R)-2-(hydroxamido carbonylmethyl)-4-methylpentanoyl]-L-tryptophane methylamide) on preventing ulceration of rabbit corneas after alkali injury. Topical treatment of corneas with severe alkali injuries with 400 microgra...

Middle cerebral artery (MCA) blood flow velocity was measured daily by transcranial Doppler ultrasonography in 121 patients with severe (50), moderate (16) and minor (55) head injury during their hospital stay, and the results compared with findings in control subjects. Admission MCA velocity was significantly lower after severe 35.8 (31.9-39.7) cm/s, mean (95% confidence limits), moderate 45.5...

BACKGROUND Subjects with moderate head injury are a particular challenge for the emergency physician. They represent a heterogeneous population of subjects with large variability in injury severity, clinical course and outcome. We aimed to determine the early predictors of outcome of subjects with moderate head injury admitted to an Emergency Department (ED) of a general hospital linked via tel...

To study the pathophysiological mechanism of progressive hypoxemia after smoke inhalation injury, alterations in ventilation-perfusion ratio (VA/Q) were studied in an ovine model by using the multiple inert gas elimination technique. Because ethane was detected in expired gas of some sheep, we replaced ethane with krypton, which was a unique application of the multiple inert gas elimination tec...

Abstract Purpose To evaluate the incidence and characteristics of brain lesions in moderate-late preterm (MLPT) infants, born at 32–36 weeks’ gestation using cranial ultrasound (cUS) magnetic resonance imaging (MRI). Methods Prospective cohort study carried out Isala Women Children’s Hospital between August 2017 November 2019. cUS was performed postnatal day 3–4 (early-cUS), before discharge re...

background & aim: traumatic brain injury is one of the main causes of death and disability. the aim of this study is to systematically review the articles which assessed some serum factors of traumatic brain injury patients in relation to their outcomes. methods & materials/patients: databases were searched for relevant publications from 2005 to 2014. selection criteria were:studies which evalu...

OBJECTIVES To identify outcomes following head injury (HI) among a population of children admitted to one hospital centre and to compare outcomes between different severity groups. METHODS A postal follow up of children admitted with HI to one National Health Service Trust, between 1992 and 1998, was carried out. Children were aged 5-15 years at injury (mean 9.8), followed up at a mean of 2.2...

Hypersensitivity to a variety of sensory stimuli is a feature of persistent whiplash associated disorders (WAD). However, little is known about sensory disturbances from the time of injury until transition to either recovery or symptom persistence. Quantitative sensory testing (pressure and thermal pain thresholds, the brachial plexus provocation test), the sympathetic vasoconstrictor reflex an...

results in the first three years, the team managed the care of 812 admissions. mean age wasn 44.3 years (sd = 24.8) and mean length of hospital stay was 6.1 days (sd = 10.9). ofn these individuals, 674 attended for 6 month follow-up with 52.2% having a good outcomen on extended glasgow outcome score. patients and their relatives' feedbacks weren excellent with an average score of 4.7/5 on overa...