The carcinogenic potential of phenobarbital (PB) was assessed in a mouse line carrying a mutant Mmh allele of the Mmh/Ogg1 gene encoding the enzyme oxoguanine DNA glycosylase (Ogg1) responsible for the repair of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Mmh homozygous mutant (Ogg1-/-) and wild-type (Ogg1+/+) male and female, 10-week-old, mice were treated with 500 ppm PB in diet for 78 weeks. Hepat...

Physiological mechanisms underlying migration remain poorly understood, but recent attention has focused on the role of the glucocorticoid hormone corticosterone (CORT) as a key endocrine regulator of migration. The migration-modulation hypothesis (MMH) proposes that baseline plasma CORT levels are elevated in migratory birds to facilitate hyperphagia and lipogenesis and that further elevation ...

Changes in urinary porphyrin excretion patterns (porphyrin profiles) during prolonged mercury exposure are attributable to mercury accumulation in the kidney and to consequent effects of Hg2+ on renal porphyrin metabolism. In the present study, we evaluated the quantitative relationship of urinary porphyrin concentrations to mobilizable renal mercury content, using the metal chelator 2,3-dimerc...

An in-shoe pressure measurement (IPM) system can be used to measure center of pressure (COP) locations, and has fewer restrictions compared to the more conventional approach using a force platform. The insole of an IPM system, however, has its own coordinate system. To use an IPM system along with a motion capture system, there is thus a need to align the coordinate systems of the two measureme...

In this paper we adopt a geometric perspective to highlight the challenges associated with solving high-dimensional reliability problems. Adopting a geometric point of view we highlight and explain a range of results concerning the performance of several well-known reliability methods. We start by investigating geometric properties of the N -dimensional Gaussian space and the distribution of sa...

The effects of daily repeated doses of monomethylhydrazine (MMH) were studied in monkeys. Groups of monkeys were given from 2.5 to 5 mg/kg IMH i.p. for a total of 23 doses. Other monkeys were given from 7 to 10 mg/kg MMH i.p. for up to 4 days. Baseline and weekly clinical laboratory measurements studied were complete blood count, serum glucose, alkaline phosphatase, and glutamic oxaloacetic tra...

This paper discusses the details of a study undertaken for biomechanical evaluation of a number of Manual Material Handling (MMH) tasks being carried out at a construction site in India. A comprehensive methodology involving a two dimensional dynamic biomechanical evaluation approach is developed for such construction MMH tasks involving carrying and lifting of materials like normal and Reinfor...

OBJECTIVE To evaluate the performance of a system that extracts medication information and administration-related actions from patient short message service (SMS) messages. DESIGN Mobile technologies provide a platform for electronic patient-centered medication management. MyMediHealth (MMH) is a medication management system that includes a medication scheduler, a medication administration re...

INTRODUCTION Low pressure valves with ventriculoperitoneal shunts have been proven to lead to good outcomes in the treatment of idiopathic normal pressure hydrocephalus. However, overdrainage complications are often seen with low opening pressures. Efforts have been made to obtain good outcomes without overdrainage complications by decreasing the hydrostatic pressure component using special val...