In this paper we develop a multi-objective model to optimally control the lead time of a multistage assembly system. The multistage assembly system is modeled as an open queueing network, whose service stations represent manufacturing or assembly operations. The arrival processes of the individual parts of the product, which should be assembled to each other in assembly stations, are assumed to...

Fish/Radiosensitivity/Colony formation/Mutagens The sensitivities of three goldfish-cell lines to the lethal effects of four carcinogens/mutagens; 4-nitro quinoline-1-oxide (4NQO), 1-methyl-3-nitro-l-nitrosoguanidine (MNNG), mitomycin C (MMC) and bleo mycin (BLM), were compared using colony-formation assay. RBCF-1 and CAF-MM1 cells were more sensitive to 4NQO, BLM and UV than were GEM 199 cells...

In this paper, we consider the batch arrival of customers to a transport station. Customers belonging each category is considered as single entity according BMMAP. An Erlang clock order m starts ticking when vessel reaches When Lth stage reached, an for next placed. The lead time follows exponential distribution. There are two types rooms in system: waiting and service station vessel, respectiv...

This paper studies a discrete-time queueing system in which customer who enters the with server occupied may choose to go retrial group or begin its service displacing that was server. If is idle arriving begins immediately. Retrial and times are general, only repeated can directly one situated at first place of group. A complete study model has been curried out noting specially analysis recurs...

The temperate phage MM1 forms stable lysogens in Streptococcus pneumoniae. We report here the first characterization of the lysogenic control region in Pneumococcus which contains two functional divergent promoters (P(R) and P(L)). MM1 encodes a 14-kDa cI protein (CI) that appears to be responsible for maintaining the lysogenic state in Pneumococcus since it prevents elongation of the transcrip...

Microbulbifer sp. CCB-MM1 is a halophile isolated from estuarine sediment of Matang Mangrove Forest, Malaysia. Based on 16S rRNA gene sequence analysis, strain CCB-MM1 is a potentially new species of genus Microbulbifer. Here we describe its features and present its complete genome sequence with annotation. The genome sequence is 3.86 Mb in size with GC content of 58.85%, harbouring 3313 protei...

Both p53-related p63 and c-Myc are transcription factors playing key roles in cell proliferation, survival, development and tumorigenesis. In the present study, we identified that MM1, a c-Myc inhibitor, specifically binds to C-termini of p63α (including ΔNp63α and TAp63α). Further study demonstrates that p63α facilitates MM1 protein degradation via proteasomal pathway, resulting in elevation o...

The present study identifies deregulated cytokines and mediators of the immune response in the frontal cortex and cerebellum of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 and VV2 subtypes compared to age-matched controls. Deregulated genes include pro- and anti-inflammatory cytokines, toll-like receptors, colony stimulating factors, cathepsins, members of the complement system, and members o...