BACKGROUND Antibiotic resistance among Staphylococcus aureus is of great concern worldwide. This resistance is further complicated by the ability of S. aureus to confer cross-resistance to other antibiotics due to the presence of resistance genes, such as erythromycin resistance methylase (erm) genes, which render the bacterium resistant to macrolide-lincosamide-streptogramin B (MLSB) antibioti...

This paper characterises low-affinity antibiotic binding interactions by the T2 (CPMG) method. Three different compounds, a ketolide ‘telithromycin’ (HMR 3647), a macrolide ‘roxithromycin’ and a lincosamide ‘clindamycin’ belonging to the macrolide–lincosamide–streptogramin B (MLSB) class of antimicrobial agents were examined against Escherichia coli, Streptococcus pneumoniae and Staphylococcus ...

Background: This study aimed to assess the psychometric properties of Persian version multiple lifestyle behaviors (MLSB) questionnaire during COVID-19 outbreak by considering role gender and exercise. Methods: research population consisted all Iranian men women in age range 18 65 years living Iran summer 2021. The statistical sample 299 female (n=225) male (n=74) athletes (of team individual d...

BACKGROUND This study assessed the antimicrobial susceptibilities and the presence of inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance in methicillin-resistant Staphylococcus aureus (MRSA) of Jamaica as well as the relatedness using polymerase chain reaction-based staphylococcal cassette chromosome mec (SCCmec) and multiple-locus variable numbers of tandem repeat analyses (MLV...

The postnatal ontogeny of potentially autoreactive T cells has been studied in a model system where a particular TCR beta chain variable domain (V beta 6) is correlated with reactivity to a minor antigen encoded by the Mlsa locus. Although absent among mature (CD4+ or CD8+) T cells in adult mice expressing Mlsa, brightly staining V beta 6+ cells were readily detectable in the thymus of neonatal...

PURPOSE Erythromycin-resistant beta-hemolytic streptococci (BHS) has recently emerged and quickly spread between and within countries throughout the world. In this study, we evaluate the antimicrobial susceptibility patterns and erythromycin resistance mechanisms of BHS during 2003-2004. MATERIALS AND METHODS The MICs of seven antimicrobials were determined for 204 clinical isolates of BHS fr...

AIMS The study was conducted to determine the prevalence of Clindamycin (CL) resistance and antimicrobial susceptibility among clinical isolates of Staphylococcus aureus (S. aureus) from Mbarara Regional Referral Hospital (MRRH) in Southwestern Uganda. STUDY DESIGN Laboratory based cross sectional study. PLACE AND DURATION OF THE STUDY The study was conducted at the Microbiology department ...

Mls determinants share with MHC products the unique property of stimulating T cells at extraordinarily high precursor frequencies. The Mls system was originally described as a single locus on chromosome 1, with four alleles, Mlsa, Mlsb, Mlsc, and Mlsd, that encode polymorphic cell surface structures. However, the fundamental issues of polymorphism and allelism in the Mls system remain controver...