BACKGROUND/AIMS Although normal endoscopic findings are, as a rule, part of the diagnosis of microscopic colitis, sev-eral cases of macroscopic lesions (MLs) have been reported in collagenous colitis, but hardly in lymphocytic colitis (LC). The aim of this study was to investigate the endoscopic, clini-cal, and histopathologic features of LC with MLs. METHODS A total of 14 patients with LC wh...

In the last years, the development of iron oxide magnetic nanoparticles (IONPs) has significantly increased with respect to other nanosized particles because of their attractive properties as theranostic agents [1]. These systems combine both, therapeutic and diagnostic properties. In order to improve their versatility and biodisponibility, IONPs can be incorporated into liposomes, resulting in...

STAT3 and Akt signaling have been validated as potential molecular targets for treatment of cancers including melanoma. These small molecule inhibitors of STAT3 or Akt signaling are promising for developing anti-melanoma therapeutic agents. MLS-2438, a novel 7-bromoindirubin, a derivative of the natural product indirubin, was synthesized with a bromo-group at the 7-position on one indole ring a...

Distributed object-oriented computing (DOC) is a new computing paradigm that promotes component-based development, location independence, scalability, software reuse, etc. Users of multilevel security (MLS) technology want to take advantage of these new technologies. However, the process of incorporating new technologies into MLS products is slower than the analogous process for non-secure comm...

T-box proteins are conserved transcription factors that play crucial roles in development of all metazoans; and, in humans, mutations affecting T-box genes are associated with a variety of congenital diseases and cancers. Despite the importance of this transcription factor family, very little is known regarding how T-box factors regulate gene expression. The Caenorhabditis elegans genome contai...

Current projects aimed at providing MLS computing services rarely seem to exploit advances in related fields. Specifically, the concepts of data distribution, replication, and interoperation are currently receiving much attention in the commercial database system sector but have yet to be applied to the delivery of MLS computing services. This paper explains how these concepts might help delive...

The present report has evaluated the differentiation compartment in which T cells are tolerized to non-major histocompatibility complex (MHC)-encoded minor lymphocyte-stimulating locus (MLS) alloantigens. It was observed that T cell precursors are not tolerized prethymically to MLS alloantigens but are tolerized intrathymically and postthymically to MLS alloantigens. The failure of prethymic T ...

We immunohistochemically investigated Epstein-Barr virus (EBV)-positive and negative 31 malignant lymphomas (MLs) for p53 protein using a monoclonal antibody which is expressed on a wild type and mutant human p53 protein. We evaluated the presence of mutations in exons 5 to 8 of the p53 gene using single-strand confirmation polymorphism analysis. Overexpression of p53 was detected in 13 out of ...

The set of cell surface determinants encoded by the MHC is remarkable in that it is recognized by naive T cell populations at a sufficiently high precursor frequency to induce substantial primary proliferative responses, and the critical biologic role played by MHC products has been well established . The only other determinants capable of inducing strong proliferative responses by naive T cell...