Clinical evidence for an abnormally of extracardiac connective tissue was sought in 21 patients with idiopathic mitral valve prolapse and was compared to that in 21 matched controls. The incidence of rheumatic and orthopaedic complaints and the prevalence of hypermobile joints, Marfanoid habitus, and skeletal deformity were compared in the 2 groups. Skin thickness and elasticity were measured, ...

Mitral valve prolapse is a common mitral valve disorder manifested clinically as a midsystolic click and/or a late systolic murmur (the click-murmur syndrome) and pathologically as billowing or prolapsing mitral leaflets (the floppy valve syndrome). Not only is it one of the two most common congenital heart diseases and the most common valve disorder diagnosed in the United States, but it is al...

BACKGROUND Myxomatous mitral valve with prolapse are classically seen with abnormal leaflet apposition during contraction of the heart. Hemodynamic disorders can result from eccentric mitral regurgitation usually caused by chordae tendinae rupture or papillary muscle dysfunction. Echocardiography is the gold standard for evaluation of leaflet flail and prolapse due to high sensitivity and speci...

To ascertain the effects of surgical closure of atrial septal defect on left ventricular geometry and degree of mitral prolapse, 14 patients with atrial septal defect were studied by cross-sectional and M-mode echocardiography preoperatively and 7 days postoperatively. Seven of the 14 patients (50%) had mitral valve prolapse preoperatively by cross-sectional echocardiography. To quantitate the ...

Sir, One should differentiate angiographic prolapse from midsystolic click, the auscultatory hallmark of the mitral valve prolapse-click syndrome. In my articles quoted by the authors, I have refuted the causal association between coronary artery disease and the midsystolic click rather than between coronary artery disease and angiographic mitral valve prolapse. In coronary artery disease, angi...

BACKGROUND Little is known about the pathophysiology of myxomatous degeneration of the mitral valve, the pathological hallmark of mitral valve prolapse, associated with symptomatic mitral regurgitation, heart failure, and death. Excess transforming growth factor (TGF)-β signaling is known to cause mitral valve degeneration and regurgitation in a mouse model of Marfan syndrome. We examined if TG...

conclusions sm wave in tdi is prominent and significantly high in mvp syndrome. also, our study showed some degree of diastolic dysfunction in mvp patients. results seventy-five patients (48 females) at a mean age of 26.5 ± 9.4 years and 50 individuals (32 females) at a mean age of 27.1 ± 8.3 years were enrolled in the study. as the important results of our study, sm wave was much more prominen...

I Beasley B, Kerber K. Does mitral prolapse occur in mitral stenosis? Echocardiographic-angiographic observalions. Chest 1981; 80:56-60 2 Howard PC, Benchimol A, Desser KB. Prolapse of the atrioventricular valves and associated mitral stenosis. A case report. Arizona Med 1978; 33:789-92 3 Weinrauch LA, McDonald DC, DeSilva R. Mitral valve prolapse in rheumatic mitral stenosis. Chest 1977; 72: 7...

A 79-year-old man was being evaluated for possible mitral valve repair for increasing mitral regurgitation. Transesophageal echocardiography with color flow Doppler showed left atrial enlargement, mitral valve prolapse, and spontaneous changes in the direction and configuration of regurgitant jets (during the same imaging study) determined by which leaflet prolapsed into the left atrium during ...

We investigated whether there is an association between anxiety disorders and mitral valve prolapse. We compared mitral valve prolapse prevalence in individuals with panic disorder (n = 41), social anxiety disorder (n = 89) and in healthy controls (n = 102) in an attempt to overcome the biases of previous studies. Our results show no associations between panic disorder or social anxiety disorde...