In 65 patients with primary invasive ductal breast carcinoma the relation between classic prognosticators describing the extent of disease (lymph node metastases and tumour size) and newer promising morphometric and DNA flow cytometric prognostic factors was studied. There was no relation between DNA ploidy, lymph node state, and tumour size. Tumours with a mitotic activity index of more than 1...

Cutaneous sweat gland carcinoma is an extremely rare malignant skin cancer which may arise from the apocrine or eccrine types of glands. It has a high mitotic index and potential [1] usually occurs in elderly people, without any gender predilection.

In vivo assessment and identification of aneuploidy are important phases of genotoxicity evaluation. Considerable effort has been devoted to assess the utility of the existing bioassays and to develop simpler techniques for identifying environmental aneugens. Salbutamol sulphate--an antiasthmatic drug was tested for its spindle damaging effects in bone marrow cells of mice using an in vivo tech...

BACKGROUND Counting mitoses is subjective and time-consuming. The adjunctive diagnostic utility of a recently reported mitotic marker, phosphohistone H3 (PHH3), was investigated in gastrointestinal stromal tumors (GISTs). METHODS We reviewed 77 GISTs for several proliferative indices. These included the mitotic count per 50 high power fields (HPFs), the immunohistochemical Ki- 67 labeling ind...

In the present study, an objective and reproducible evaluation of mitotic activity and nuclear morphometric factors was attempted in 30 patients of oral squamous cell carcinoma with a view to predicting local relapse and survival. Various nuclear parameters and volume-corrected mitotic index were calculated and compared with the recurrence and death of the study group (n = 30). Volume-corrected...

BACKGROUND Quantitative methods in combination with other objective prognostic criteria can improve the evaluation of a cancer patient's prognosis, and possibly predict response to therapy. One of the important prognostic and predictive markers is the mitotic count, which has proven valuable in many aspects. In this study, the prognostic value of the mitotic count was assessed in breast cancer ...

PURPOSE To evaluate the early histological effects of the intravesical instillation of platelet-rich plasma (PRP) in rabbit models of interstitial and hemorrhagic cystitis. METHODS Thirty-six rabbits were classified into 6 groups: saline (S), S+PRP, hydrochloric acid (HCl), HCl+PRP, cyclophosphamide (CyP), and CyP+PRP. At 48 hours after induction, PRP was prepared and intravesically administe...

By SVEN-AGE KILLMANN, EUGENE P. CRONKITE, T. M. FLIEDNER AND VIc’roR P. BOND T HE OBJECTIVES of the present papers are threefold: In part I, data on the mitotic indices of specific cell types ( specific mitotic index ) in normal human bone marrow will be presented. In part II, restrictions in the use of mitotic index for computation of cytologic time parameters which have not been appreciated i...