neuroserpin, a member of the serine proteinase inhibitor (serpin) superfamily, is known to be a neuroprotective factor in the focal ischemic stroke followed by reducing the microglial activation. neuroserpin is a protein rich of methionine residues that can scavenge the free radical species which may increase its neuroprotective effect. on the other hand, the oxidative modifications of the amin...

background: combination of glycation and oxidation is associated with diabetes mellitus. the aim of this study was to clarify the effect of glycated proteins in presence of transition metal ions on production of reactive oxygen species (ros) in rat hepatocyte suspension.  methods: glycated albumin was prepared by incubation of bovine serum albumin with 100 mm glucose in 0.3 m phosphate buffer a...

objective(s) neutrophil gelatinase-associated lipocalin (ngal/lcn2), comprise a group of small extracellular proteins with a common p-sheet-dominated 3-dimensional structure. in the past, it was assumed that the predominant role of lipocalin was acting as transport proteins. recently it has been found that oxidative stress induces lcn2 expression. it has been also proved that electromagnetic fi...

under prolonged diabetic conditions, hba1c is produced from normal hemoglobin (hba0) through a non-enzymatic glycosylation or glycation, a process which enhances the hemoglobin susceptibility to be auto-oxidized to methemoglobin (methb). here we are reporting that the non-enzymatic reaction between fructose and methb (methb fructation) induces significant changes in the globin structure and deg...

Common techniques for the treatment of Hepatocellular carcinoma (HCC) have not been successful, and thus the design and discovery of new compounds with better anti-cancer function are needed. Snake venom is among the most important compounds used by researchers to the treatment of various cancers. This study was designed to evaluate the toxicity effect of Persian Gulf snake venom (Enhydrina sch...

reactive oxygen species cause to release of dormancy in many plants such as sunflower seeds. this study investigated in order to evaluation role of reactive oxygen species germination and lipid proxidation in sunflower seeds. this study was performed in two separate experiments, each in a completely randomized design with factorial design with four replications.  in both experiments, uses from ...

background: excess reactive oxygen species (ros) in the semen is believed to affect fertility in men. morphologically abnormal sperms and their relation to seminal oxidative stress in infertile and subfertile men are not clear. objective: to correlate various sperm morphological defects with seminal oxidative stress in infertile and subfertile men. materials and methods: the study included 25 p...

to find the protective role of exogenous nitric oxide (no) on salinity-stressed rice seedlings, a crd-based factorial experiment with three replications was conducted in agronomy laboratory of the faculty of agricultural sciences, university of guilan, in 2012. the experimental design consisted of healthy and vigorous seedlings of two rice cultivars, khazar and goohar, the last already known as...

drought stress is one of the serious problems that restricted agronomic plant production worldwide. inmolecular level, the harmful effect of drought stress is mostly caused by producing of large amount ofreactive oxygen species (ros). catalase and metallothionein genes have a crucial role to mope the hydrogenperoxide (h2o2) resulting reducing oxidative damage. in this research the gene expressi...

background: lead, an example of heavy metals, has, for decades, being known for its adverse effects on various body organs and systems such that their functions are compromised. objective: in the present study, the ability of lycopersicum esculentum on decrease toxic effects of lead acetate on plasma superoxide dismutase, catalase and malondialdehyde in rat. lead to adversely affect the liver t...