Objective(s): Menopause and diabetes obviously increase the risk of cardiovascular disease in women. The aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of miRNA-29, miRNA-133, IGF-1 and Bcl-2 genes and Bcl-2 protein and caspase 3 activity in the hearts of female rats. Materials and Methods: Forty Female Wistar rats were ...

the importance of nanotechnology in medical technologies, especially biomedical diagnostics, is indubitable. by taking advantages of nanomaterials, many medical diagnostics methods have been developed so far, including electrochemical nanobiosensors. they have been used for quantification of different clinical biomarkers for detecting, screening, or follow up a disease. micrornas (mirnas) are o...

single-nucleotide polymorphisms (snps) in mirnasmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. our study aimed to evaluate the possible association between mirna-146a rs2910164 and mirna-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (ptb) in a sample of iranian population. this case- control study was perfor...

Abstract Background Autism spectrum disorder is a condition related to brain development that affects person’s perception and socialization, resulting in problems social interaction communication. It has no single known cause, yet several different genes appear be involved autism. As genetically complex disease, dysregulation of miRNA expression miRNA–mRNA interactions might feature autism diso...

Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...

MicroRNA (miRNA) has emerged as a promising alternative therapeutic treatment for cancer, but its delivery been hindered by low cellular uptake and degradation during circulation. In this review, we discuss the various methods of delivering miRNA, including viral non-viral systems such liposomes nanoparticles. We also examine use nanoparticles miRNA-based diagnostics. focus specifically on util...

Phase-separated biomolecular droplets are formed in cells to regulate various biological processes. This phenomenon can be applied constructing self-assembled dynamic molecular systems such as artificial and robots. Recently, programmable phase-separated called DNA have been reported a possible method construct systems. study reports computational droplet that recognize specific combination of ...