to improve the accuracy of the activity quantification and the image quality in scintigraphy, scatter correction is a vital procedure. the aim of this study is to compare the accuracy in calculation of absorbed dose to patients following bone scan with 99m tc-marked diphosphonates ( 99m tc-mdp) by two different methods of background correction in conjugate view method. this study involved 22 pa...

background: therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153sm]-samarium maltolate was developed for possible therapeutic applications. materials and methods: the or...

A brief overview is provided of the history of the development of internal dose methods for use in nuclear medicine. Basic methods of internal dosimetry and the systems that have been developed for use in nuclear medicine are described. The development of the MIRD system and the International Radiopharmaceutical Dosimetry Symposium series is outlined. The evolution of models and tools for calcu...

Introduction: In patients with thyroid carcinoma, radiation absorbed doses of the thyroid and surrounding tissues is important to weigh risk and benefit considerations. In nuclear medicine, the accuracy of absorbed dose of internally distributed radionuclides is estimated by different methods such as MIRD and direct method using TLD. The aim of this study is using TLD and a phantom to determine...

In collaboration with the MIRD Committee, Society of Nuclear Medicine: E.E. Watson (Chair), J.S. Robertson (Task Group Leader), W.E. Bolch, A.B. Brill, N.D. Charkes, D.R. Fisher, M.T. Hays, R.W. Howell, J.A. Siegel, S.R. Thomas and B.W. Wessels Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida; Gaithersburg, Maryland; Department of Radiology, George...

Abstract Background Patients with metastatic, castration-resistant prostate cancer (mCRPC) present an increased tumor burden in the skeleton. For these patients, Lutetium-177 (Lu-177) radioligand therapy targeting prostate-specific membrane antigen (PSMA) has gained increasing interest promising outcome data. Patient-individualized dosimetry enables improvement of success aim minimizing absorbe...

introduction: radioactive materials deliver internal radiation dose to patients in nuclear medicine. manual internal radiation dose assessment is a complicated method. introduction of a simple dose calculation software is the main goal of the present study. methods: using the best current data in internal dose calculation (s-factors) recommended by icrp and by considering other technical metho...

BACKGROUND Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 (18F) Injection in six healthy volunteers (HVs), four males and two females, up to approximately 5 h post-injection. For each subject, key organs and tissues were delineated and analytical fits were made to the image data as functions of time to yield...