نتایج جستجو برای: minimal bactericidal concentration

تعداد نتایج: 533231  

Journal: :Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 1995
T Morooka H Matano S Yamaguchi M Shibata

Campylobacter fetus is a rare etiological agent of neonatal meningitis. However, it is a clinically significant bacterium because many cases of neonatal meningitis caused by C. fetus result in death or severe sequelaen. Recently, two new carbapenem antibiotics, meropenem (MEPM) and panipenem (PAPM), which possess relatively good ability to penetrate into the cerebrospinal fluid and a lower risk...

Journal: :Antimicrobial agents and chemotherapy 1979
P Vaudaux F A Waldvogel

Complete protection of Staphylococcus aureus Wood 46 from gentamicin bactericidal activity was documented for microorganisms located within polymorphonuclear leukocytes. The highest, still ineffective gentamicin concentration tested in the phagocytic assay was 80 times higher than the minimal concentration required to kill uningested organisms. Extracellular gentamicin activity was unaffected b...

2003
PIERRE VAUDAUX

Complete protection of Staphylococcus aureus Wood 46 from gentamicin bactericidal activity was documented for microorganisms located within polymorphonuclear leukocytes. The highest, still ineffective gentamicin concentration tested in the phagocytic assay was 80 times higher than the minimal concentration required to kill uningested organisms. Extracellular gentamicin activity was unaffected b...

Journal: :Journal of clinical pathology 1982
F Soriano M C Ponte M C Gaspar

We have studied the antimicrobial action of metronidazole against Bacteroides fragilis and Escherichia coli both in pure cultures and in combination. Concentrations of metronidazole above the minimal inhibitory concentration (MIC) produced a marked bactericidal effect on B fragilis at six hours. E coli however showed only a slight and transitory decrease in population when exposed to concentrat...

Journal: :Antimicrobial agents and chemotherapy 2009
Nacer Lounis Tom Gevers Joke Van den Berg Luc Vranckx Koen Andries

The efficacy of ATP synthase inhibitor TMC207 was assessed in early and late Mycobacterium avium infections in mice. In contrast to what was earlier observed for M. tuberculosis, a bacteriostatic effect was obtained. In vitro, the minimal bactericidal concentration (MBC)/MIC ratio was very high. The MBC was more relevant for assessment of pharmacokinetic/pharmacodynamic relationships than the MIC.

Journal: :Archives of disease in childhood 1983
D P Heaf G J Webb D J Matthew

The minimal inhibitory concentration of azlocillin for Pseudomonas aeruginosa is appreciably reduced when combined with the mucolytic agent mesna (Mistabron) because of an independent bacteriostatic effect of mesna. Bactericidal activity of azlocillin is unaltered by mesna. Mesna inhalations alone or combined with azlocillin may benefit cystic fibrosis patients with pseudomonas lung infections.

Journal: :Antimicrobial agents and chemotherapy 1976
J P Hieber J D Nelson

It was recently reported that the dosage of kanamycin formerly recommended for neonates of 7.5 mg/kg every 12 h did not produce therapeutic serum concentrations of 15 to 25 mug/ml, but a larger dosage of 10 mg/kg every 12 h was required. Reevaluation of the pharmacokinetics of kanamycin in infants and children was therefore undertaken. Sixteen time-concentration curves after a dose of 5 mg/kg w...

ژورنال: طب جنوب 2019
Askari , Azam, Mahmudpour , Mehdi, Yousefi , Forogh,

Background: Acinetobacter baumannii is an opportunistic pathogen and a nosocomial infection agent. Antibiotic resistance in this organism results in serious health problem such as treatment failure and increased mortality. Mangrove plants, especially Avicennia marina, are a potential bioresource for new drugs as they have been used in traditional medicine. This study aimed to investigate antib...

Journal: :Colloids and Surfaces B: Biointerfaces 2021

In this work the quantification of antimicrobial properties differently sized AgNPs immobilized on a surface was studied. Three different sizes spheroidal with diameter (6, 30 and 52) nm were synthetized characterized UV–vis, SEM, TEM ICP-MS. The MIC (Minimal Inhibitory Concentration) MBC Bactericidal against Escherichia coli investigated. Then, antibacterial efficacy (R) amino-silanized glasse...

Journal: :Antimicrobial agents and chemotherapy 1984
C Odio N Threlkeld M L Thomas G H McCraken

The pharmacokinetic properties of mezlocillin were evaluated in newborn infants. Mean peak and trough concentrations of drug in plasma, after 75 mg of mezlocillin per kg given intravenously, were 252 and 72 micrograms/ml, respectively, in infants who were less than 38 weeks gestation and less than or equal to 7 days old, compared with 139 and 9 micrograms/ml, respectively, in infants greater th...

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