OBJECTIVE To examine lymphatic microvessel density (LMVD) in primary pterygia. METHODS We included tissue samples from 88 excised primary (including 34 grade 1, 28 grade 2, and 26 grade 3) pterygia and from 7 nasal epibulbar conjunctivae segments used as control samples. Sections from each pterygium were immunostained with CD31 and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) m...

This study tested the hypothesis that chronically elevated oxidant stress contributes to impaired active hyperemia in skeletal muscle of obese Zucker rats (OZR) vs. lean Zucker rats (LZR) through progressive deteriorations in microvascular structure. Twelve-week-old LZR and OZR were given 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (tempol) in the drinking water for approximately 4 wk. Subse...

Introduction Among head and neck cancers, those of the oral cavity and oropharynx are the second most prevalent following the larynx. This study aimed to research immunohistochemical expression of survivin, HPV positivity and microvessel density in tumors and their relationships with prognosis. Material and methods Pathological materials and demographic properties of 46 patients were retrospe...

BACKGROUND AND AIMS The role of angiogenesis in progression and metastasis of gastric cancer has been studied over the last years. The aim of our study was to assess the microvessel density and vascular endothelial growth factor (VEGF) expression in correlation with prognosis, survival and the risk for upper gastrointestinal (GI) bleeding as well. METHOD We prospectively assessed angiogenesis...

Munzenmaier, Diane H., and Andrew S. Greene. Chronic angiotensin II AT1 receptor blockade increases cerebral cortical microvessel density. Am J Physiol Heart Circ Physiol 290: H512–H516, 2006. First published September 30, 2005; doi:10.1152/ajpheart.01136.2004.—Angiotensin II is known to stimulate angiogenesis in the peripheral circulation through activation of the angiotensin II type 1 (AT1) r...

CONTEXT AND OBJECTIVE Morphological changes in the spiral arteries of the placental bed have been studied in patients with preeclampsia, one of the largest causes of maternal and perinatal morbidity and mortality. The reports show that vasospasm and vascular endothelial injury were two major pathological conditions for preeclampsia. The aim of this study was to investigate the microvessel densi...

To investigate the role of angiogenesis in multiple myeloma (MM), bone marrow biopsy from 75 adults with newly diagnosed, untreated MM were evaluated. Microvessels were scored in at least 3 areas ( x 200 fields) of the highest microvessel density in representative sections of each bone marrow specimen using immunohistochemistry for CD34. Prognostic variables were also evaluated for the overall ...

abstract background and aims. reliable immunohistochemical assays to evaluate the definitive role of mast cells and angiogenesis in the pathogenesis of oral reactive lesions are generally not available. the purpose of the present study was to compare mast cell count (mcc) and microvessel density (mvd) between oral reactive lesions and evaluation of the correlation between mcc and mvd in these l...