Gastric cancer (GC) is one of the most common types of cancer and the second leading cause of cancer-associated mortality. Identification of novel biomarkers is critical to prolonging patient survival. MicroRNAs (miRNAs) proved to play diverse roles in the physiological and pathological state in cancers including GC. Herein we were aimed at performing a meta-analysis on miRNA profiling studies ...

as an aromatic and colorful plant of substantive taste, saffron (crocus sativus l.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. regarding the critical role of micrornas in secondary metabolic synthesis and the limited number of identified mirnas in c. sativus, on the other hand, one may see the point how the characte...

micrornas (mirnas) are small preserved non-coding rna molecules that regulate gene expression post-transcriptionally by targeting the 3' utr of mrnas for translational repression or degradation. the rising evidence has established the significant role of mirnas within the regulation of immune system and the prevention of autoimmunity. mir-146a has obtained an importance as a modulator of d...

Objective(s): The purpose of this study was to conduct a meta-analysis on human microRNAs (miRNAs) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. Materials andMethods: PubMed, Embase, Web of Science, Ovid Medline were used to search for endometriosis miRNA expression profiling studies of endometriosis. The miRN...

Background and objectives: Curcumin as a medicinal substance has shown effective in different kinds of diseases especially cancer. To understand its underlying mechanism, molecular complementary study of differentially expressed microRNAs (DEMs) could assist. In this view, regulatory network analysis of DEMs of melanoma cancer treated with curcumin versus the untreated male <em...

MicroRNAs (miRNAs) related to phytohormone signal transduction and self-incompatibility may play an important role in the xenia effect. However, associated research this area is still lacking rabbiteye blueberry ( Vaccinium ashei ). In study, we identified miRNAs, predicted their target genes, performed functional enrichment analysis of screened for miRNAs signaling self-incompatibility. A tota...

MicroRNAs (miRNAs) are known as a new class of small RNAs (18-25 nucleotides) that regulate gene expression at multiple levels from transcription to translation. Considering the important role of miRNAs in cell proliferation, differentiation, and apoptosis, any variations in their expression can contribute to various anomalies, such as tumorigenesis. Single-nucleotide polymorphisms (SNPs) have ...

Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed Microprocessor that composed of RNase enzyme Drosha and DGCR8, the second another Dicer. There many examples miRNAs poor substrates for Dicer, owing to their suboptimal structures. However, a number these known be expressed at same or higher level as neighboring structurally-optimal m...