Micronucleus is similar to the nucleus, but smaller, formed in the cell due to damage of chromosomes by external factors. Incidence of micronuclei is scored in different cell lines as a parameter to evaluate the genotoxicity of chemicals and radiation. Bone marrow micronucleus assay in rodents, particularly in mice, has been the most popular technique used to screen the chemicals for their toxi...

individuals handling antineoplastic drugs or their wastes may absorb these potent genotoxic agents. the effects of handling antineoplastic drugs were examined in a group of 24 nurses working in the hematology and oncology departments of two different university hospitals in shiraz (iran) and in a group of 18 unexposed nurses as control group. the cytogenetic repercussions of exposure were asses...

BACKGROUND To determine the possible genotoxic effect of exposure to the smoke generated by biomass burning on workers involved in manual sugar cane harvesting. METHODS The frequency of micronuclei in exfoliated buccal cells and peripheral blood lymphocytes was determined in sugarcane workers in the Barretos region of Brazil, during the harvest season and compared to a control population, com...

Components of resin materials may damage DNA, leading to genetic alterations in mammalian cells. Here, monomers were analyzed for the induction of chromosomal aberrations indicated by micronuclei induced in V79 cells. A dose-related increase in the numbers of micronuclei was observed with triethyleneglycol dimethacrylate (TEGDMA), 2-hydroxyethyl methacrylate (HEMA), and glycidyl methacrylate (G...

One of the most common characteristics of cancer cells is genomic instability. Recent research has revealed that G2/M-phase checkpoint adaptation-entering mitosis with damaged DNA-contributes to genomic changes in experimental models. When cancer cells are treated with pharmacological concentrations of genotoxic agents, they undergo checkpoint adaptation; however, a small number of cells are ab...

background: a radioprotective effect of amifostine as well as its ability to modulate the level of spontaneous and gamma-irradiation-induced genetic changes on human peripheral blood lymphocytes has been investigated . amifostine, known as a potent radical scavenger, has been introduced as the most effective radioprotector, yet it is not completely approved for the clinical use. however, furthe...

objective: micronuclei are induced in cells by a variety of substances, like uv radiation, infrared rays, x-radiations, and chemicals. among them tobacco- specific nitrosamines have been reported to be potent mutagenic agents which are thought to be responsible for the induction of chromosomal aberrations resulting in production of micronuclei. the main aim of our study is to compare mn frequen...

The present investigation was undertaken to explore the Antimutagenicity activity of Terminalia chebula on micronucleus formation and chromosomal aberration assay in bone marrow cells of Swiss albino mice. The protective effect of Terminalia chebula extract is reported against cyclophosphamide (CP)-induced micronuclei formation and chromosomal aberration in mouse bone marrow cells. The doses na...

background : we intend to study the inhibitory effect of sulfur compound in ramsar hot spring mineral on tumor-genesis ability of high natural background radiation. objective : the radioprotective effect of sulfur compounds was previously shown on radiation-induced chromosomal aberration, micronuclei in mouse bone marrow cells and human peripheral lymphocyte. ramsar is known for having the high...