In pharmaceutical industries, most active pharmaceutical ingredients are poorly water soluble, and therefore milling processes are important to obtain fine particles that can be easily dissolved in the body. However, the main purpose of milling is micronization of particles. From the viewpoint of fine particle preparation in the formulation process, milling has not been investigated sufficientl...

Solid-liquid equilibria of solid mixtures in compressed CO2 are very important in assessing the feasibility of gas-assisted micronization processes such as PGSS (Particles from Gas-Saturated Solution). The determination of solid-liquid transition temperatures, the eutectic temperature and the associated composition of the melt can be problematic and time-consuming. Such data are required in the...

One of the most important environmental concerns for the polymer industry is to produce new products with near-zero residual monomer content. A new process based on supercritical CO2 has been successfully tested for the extraction of the residual monomer and the simultaneous micronization of the polymer. The process has been tested on a pilot-scale plant. The reduction of methyl methacrylate (M...

Two experiments were conducted to determine the effects of micronization (infrared heat treatment), dehulling, or enzyme supplementation on the nutritive value of three cultivars (Impala, Radley, and Sirius) of peas in laying hens. In Experiment 1, 280 White Leghorn hens were fed diets containing micronized and dehulled peas for a period of 12 wk. The dietary inclusion of peas was 600 g/kg (cor...

Along the line that health-beneficial foods must also be accompanied by sustainable agricultural practices, red alga Lithothamnium sp. (Rhodophyta), frequently used for animal and human nutrition, it was shown could a biofertilizer, regarding their bioactive humic acid content, released micronization. Also, onions present well-known benefits to health are among main vegetable crops grown worldw...

Crude topiramate was prepared from the reaction between diacetonefructopyranose, sulfuric diamide, and 2-picoline. During a controlled processing the presence of Triton-X-100, crude topiramate in a methanol-water solvent, was converted to pure micron size topiramate particles. The factors affecting the purification and micronization of topiramate, such as solvent and anti-solvent type and conce...