P2 receptors are membrane-bound receptors for extracellular nucleotides such as ATP and UTP. P2 receptors have been classified as ligand-gated ion channels or P2X receptors and G protein-coupled P2Y receptors. Recently, purinergic signaling has begun to attract attention as a potential therapeutic target for a variety of diseases especially associated with gastroenterology. This study determine...

BACKGROUND Ductal carcinoma in situ is a non-invasive carcinoma that is unlikely to recur if completely excised. Margin width, the distance between the boundary of the lesion and the edge of the excised specimen, may be an important determinant of local recurrence. METHODS Margin widths, determined by direct measurement or ocular micrometry, and standardized evaluation of the tumor for nuclea...

The study was conducted to know the copro-prevalence of hookworm infection in relation to various risk factors in the pet dogs from in and around Ludhiana. Total 250 dog faecal samples were examined by flotation and Mc Master egg counting technique for qualitative and quantitative evaluation, respectively. The prevalence of hookworms was correlated with meteorological data, age, sex and breed. ...

Dronedarone is a multichannel blocking antiarrhythmic drug that has been used for management of atrial fibrillation in humans, but the data in veterinary medicine are inadequate. The objective of this study was to determine the short-term effects of oral dronedarone on cardiac inotropy and lusitropy, blood pressure and electrocardiogram (ECG) in healthy dogs. A total of 6 beagle dogs were instr...

This research was carried out to define the morphological features of infundibulum and magnum in turkey and pigeon. For this purpose, a total of 10 adult healthy turkey (No=5) and pigeon (No= 5) were used. After dissecting, infundibulum and magnum of each specimen was separated by incision and fixed in 10% buffered formalin. For histological studies, after tissue preparation and staining with H...

This study was undertaken to determine the impact of sarcomere length (SL) on the level of cooperative activation of the cardiac myofilament at physiological [Mg2+]. Active force development was measured in skinned rat cardiac trabeculae as a function of free [Ca2+] at five SLs (1.85-2.25 microm; 1 mM free [Mg2+]; 15 degrees C). Only muscle preparations with minimal force rundown during the ent...

BACKGROUND A method is needed to identify nonstenotic, lipid-rich coronary plaques that are likely to cause acute coronary events. Near-infrared (NIR) spectroscopy can provide information on the chemical composition of tissue. We tested the hypothesis that NIR spectroscopy can identify plaque composition and features associated with plaque vulnerability in human aortic atherosclerotic plaques o...

OBJECTIVES Optical coherence tomography (OCT) is an imaging modality that uses a broadband light source to produce high-resolution cross-sectional images in living tissue (8-20 microm). A prospective study of normal, benign, and pathologic tissues in the pediatric airway was conducted to assess the utility of OCT technology in characterizing the microanatomy of the pediatric upper aerodigestive...

BACKGROUND Atherosclerotic plaque progression is frequently accompanied by compensatory enlargement to preserve the lumen. These enlarging plaques develop features of vulnerability, however, leading to disruption and lumen obstruction. This complex transition from compensatory expansion to plaque disruption may not derive solely from progressive intimal disease. Concurrent changes at the intimo...

The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little known about its function pain. It acts through the NK1 receptor, several effects are mediated by a yet unidentified target. Therefore, we investigated role mechanism of action HK-1 arthritis models distinct mechanisms with special emphasis on Arthritis was induced i.p. K/BxN serum (passive tran...