The goal of this study was to develop a parenteral microemulsion formulation of cyclosporine A (CyA). The CyA solubility in caprylic capric triglyceride (GTCC), ethyl oleate and soybean oil were determined. The pseudo-ternary diagrams of oil (GTCC), surfactant (Solutol® HS-15), cosurfactants (ethanol/polyethylene glycol 400 [PEG 400] mixture) and water were constructed to identify boundaries fo...

The objective of the present study was to design and develop a microemulsion based transungual drug delivery formulation of ciclopirox olamine using colloidal carrier for treatment of onychomycosis. Capmul PG8 was selected as oil phase due to the high solubility of ciclopirox in it as compared to other oils and Cremophor EL and Transcutol P were used as surfactant and cosurfactant respectively....

Changing the formulation variables of microemulsion systems has a significant influence on the resulting transdermal enhancement effect. NMR diffusion-ordered spectroscopy (DOSY) can offer an extremely valuable tool to interpret the differences in the obtained fluxes based on variations in self-diffusions between the drug and its locus domain. From the clinical editor: Microemulsion systems are...

A novel functional KH₂PO₄ (KDP) aqueous solution-in-oil (KDP aq/O) microemulsion system for KDP crystal ultra-precision chemical-mechanical polishing (CMP) was prepared. The system, which consisted of decanol, Triton X-100, and KH₂PO₄ aqueous solution, was available at room temperature. The functional KDP aq/O microemulsion system was systematically studied and applied as polishing solution to ...

In the present work, levofloxacin based microemulsion was developed and its usefulness as topical drug carrier system for anti bacterial activity was investigated. Microemulsion was prepared by phase titration method using oleic acid as oil phase, tween-60 as surfactant and isopropyl alcohol as co-surfactant. Five different formulations were formulated with various amount of the oil, water and ...

The aim of the present study was to prepare, characterize and in-vitro evaluation of a Winsor-IV type microemulsion based drug delivery system incorporating celecoxib as BCS class–II model drug. Attempts were made to prepare cost effective O/W microemulsion using Tween 80, Glycerol, sunflower oil and water. The existence of microemulsion zone was investigated using phase diagrams. The systems w...

We propose that one can deduce very insightful information regarding the drug and fatty acid binding capacity of microemulsions through simple turbidity experiments. Pluronic F127-based oil-in-water microemulsions of various compositions were synthesized and titrated to turbidity with concentrated amitriptyline, an antidepressant drug. We observed that, above certain Pluronic F127 concentration...

We predict, qualitatively, the structural transitions in microemulsion systems induced by nonionic polymers, by virtue of their ability to associate with the surfactant assemblies. The predictions are made possible by linking (a) theoretical calculations of the domains of existence of oil-in-water (O/W) and water-in-oil (W/O) droplet microemulsions with (b) the experimental observation that on ...