Background & Importance: The aim of this study was to demonstrate the result of transsphenoid microsurgery for Cushing disease in our center and comparing the results in details with other articles, to achieve the best decision for patients management in future. Case Presentation: Between 1991 to 2015, 50 patients suffering from Cushing disease were operated. Before operation, endocrine t...

The aim of the present study was to determine whether BCL6 is expressed during malignant transformation of the large bowel and to assess whether, and to what extent, immunoreactivity is related to the different stages of neoplastic progression. Samples of normal colorectal mucosa (n=22), microadenomas (n=22) and colorectal cancer (n=22), were analyzed by immunohistochemistry, immunofluorescence...

It is sometimes difficult to confirm the location of a microadenoma in Cushing disease. Recently, we experienced an 11-yr-old female case of Cushing disease with hyperprolactinemia. She was referred to our hospital because of decrease of height velocity with body weight gain. On admission, she had typical symptoms of Cushing syndrome. Although no pituitary microadenomas were detected on 1.5 Tes...

This video demonstrates an endoscopic transsphenoidal resection of an corticotropin-secreting pituitary microadenoma. The patient is a 62-year-old man who was found to have a 5-mm pituitary adenoma after he exhibited signs and symptoms of Cushing disease. His endocrine laboratory studies confirmed central hypercortisolism.This video highlights dissection of the adenomapseudocapsule from the rem...

Foci of aberrant crypts similar to those seen in experimental animals exposed to colon carcinogens have been identified and quantified on the mucosal surface of fixed resections of human colon after methylene blue staining. Many of the foci in humans showed dysplasia on histologic examination and were considered to be microadenoma (MA). These lesions may be precursors for adenomatous polyps and...

Cabergoline, a dopamine agonist agent, is commonly used in the treatment of hyperprolactinemia, Parkinson's disease, restless leg syndrome, and antipsychotic-induced prolactin elevation. It is generally well tolerated as compared to other dopamine agonist agents due to its more selective D2 receptor agonistic effect. We present a case of a 25-year-old female who developed manic episode, followi...

1 Cushing’s Disease Manifesting as Multiple Pituitary Adenomas With Corticotroph Hyperplasia Anupam Srivastava, MD, and Romesh K. Khardori, MD, FACE A 51-year-old man presented with chief complaints of proximal muscle weakness and drooping of eyelids. An initial diagnosis of seronegative myasthenia gravis was made, and he was empirically treated with corticosteroids, which made his symptoms wor...