We study the growth of an implanted avascular tumor in rats, in two-dimensions, based on a model where the mechanism of invasion is centered on tumor-induced acidification of the micro-environment and consequent death of normal cells. The spatial distribution of the acid density around the tumor is found using mean-field analysis. By assuming that the viability of both normal and tumor cells fa...

Stent is a metal mesh tube for opening the obstructed vessels of the body. Ni-Ti alloy is a suitable metal for fabrication of stent due to its potential for applying the appropriate stress and strain to the vessel walls. In this study, super-elastic Nitinol wire was used to build stent samples usable to open femoral vessel. Ageing was performed at 500°C for different periods of time to determin...

PURPOSE To assess the optical coherence tomography angiography (OCTA) retinal vessel density and foveal avascular zone (FAZ) in children with type 1 diabetes (T1D) and compare potential pathologic early changes in this population to healthy age-matched controls. METHODS This study included 130 pubescent children: 94 with T1D (188 eyes) and 36 of their age-matched control group (60 eyes). OCTA...

PURPOSE To evaluate optic nerve vascular density using swept source optical coherence tomography angiography (OCTA) in patients with early primary open angle glaucoma (POAG), pre-perimetric glaucoma and normal eyes. METHODS This is a prospective, observational study including 56 eyes in total and divided into 3 groups; 20 eyes with mild POAG, 20 pre-perimetric glaucoma eyes, and 16 age-matche...

Within 10 days after implantation of Porous silk fibroin film (PSFF) into hypodermal tissue of rat, it was observed that the micro vascular network system had been formed in materials [1] and the arterioles were found in materials, which shows that in the process of capillary formation, the arterioles development is also underway simultaneously [2,3]. There are a lot of reports about the angiog...

Neurological degeneration can occur after compression of the spinal cord. It is widely accepted that spinal cord compression leads to ischemic lesions and ultimately neurological dysfunction due to a narrowed spinal canal. Therefore, an in-depth understanding of the pathogenesis of spinal cord compression injury is required to help develop effective clinical interventions. In the present study,...

A tumor vasculature network undergoes intense growth and rebuilding during tumor growth. Traditionally, vascular networks are histologically examined using parameters such as vessel density determined from two-dimensional slices of the tumor. Two-dimensional probing of a complicated three-dimensional (3D) structure only provides partial information. Therefore, we propose the use of microcompute...

Using cryostatic microscopic computed tomography (micro-CT), we sought to determine the role of coronary vasa vasorum (VV) in transendothelial solute transport in arteries with normal and increased permeability due to high plasma cholesterol levels. In 6-mo-old pigs on a normal (n=23) and 2% high cholesterol (HC) diet (n=8), 2-cm segments of the proximal left anterior descending coronary arteri...

OBJECTIVE To explore the effect of low-energy extracorporeal shock wave therapy to improve myocardial micro-vascular circulation after acute myocardial infarction at the early stage in pig model. METHODS A total of 25 domestic pigs were used in this study. Model of acute myocardial infarction (AMI) was created successfully by the implantation of angioplasty balloon in mid-distal segment of le...

1254 May 2014 H micro-ultrasound is a new, preclinical technology that utilizes higher frequencies compared to conventional ultrasound. During a feasibility trial using high-frequency micro-ultrasound for vascular access in children, radial artery spasm in an 8-month-old male child was uniquely documented with a 50-MHz probe. The intraluminal diameter before attempted cannulation was 2.1 mm (fi...