The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...

The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...

Backgrounds: It remains unclear whether radiation-induced haemorrhage in the spleen causes iron accumulation, and subsequently, ferroptosis in splenic lymphocytes. In this study, we investigated the occurrence of ferroptosis in splenic lymphocytes of gamma-irradiated mice. Materials and Methods: Mice were subjected to gamma radiation from a 137Cs source. Iron, Ferroportin 1, and iron regulatory...

The antitumor activity of ethanol extract of Prosopis glandulosa Torr. (EPG) was evaluated against Ehrlich ascites carcinoma (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantl...

Introduction: The use of cell phones is widespread and there are public concerns regarding its possible deleterious effects on human health especially on the pregnancy outcomes. In this study, structural changes of the placenta after applying the cell phone radiation were examined in the mice model.   Materials and methods: For this work, 40 pregnant Balb/C mice were randomly allocated to ...

the aim of this study was to evaluate antitumour activity of the roots of hibiscus tiliaceus linn. against dalton’s ascitic lymphoma (dal) in swiss albino mice. a significant enhancement of mean survival time (mst) of h. tiliaceus treated tumour bearing mice was found with respect to control group. h. tiliaceus treatment was found to enhance peritoneal cell counts. when these h. tiliaceus treat...

BACKGROUND: Lifelong consumption of a Western-style diet is risk factor for developing metabolic disorders and therefore impairs healthy aging. Dietary restriction (DR) could delay the onset age-related diseases prolong life span, however, extent to which this depends on type poorly understood. OBJECTIVE: To study whether feeding affects aging benefits DR. METHODS: Mice fed (ad libitum DR) were...

Objective(s): Zonula occludens proteins (ZO-1 and ZO-2) are important intracellular tight junction (TJ)-associated proteins that link the cell cytoskeleton to the trans-membrane TJ proteins.  Destruction of TJ proteins is called the “leaky gut syndrome” and has been observed in some of the gastrointestinal diseases such as the inflammatory bowel disease (IBD). So, ther...

background: in some areas of ramsar, a city in northern iran, residents receive a much higher annual radiation exposure than is permitted for radiation workers. induction of adaptive response in residents of ramsar has been reported previously. in this study induction of such a response in short term exposure to high background levels of gamma radiation is investigated. materials and methods: f...