Abstract MHC class I (MHC‐I) molecules undergo an intricate folding process in order to pick up antigenic peptide present the immune system. In recent years, discovery of a new editor for MHC‐I has added extra level complexity our understanding how presentation is regulated. On top this, incredible diversity leads significant variation interaction between and components antigen processing pathw...

Objective(s): Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats.Materials and Methods: Diabetes was i...

molecular understanding of three-dimensional (3d) peptide: mhc models require both basic knowledge of computational modeling and skilled visual perception, which are not possessed by all students. the present model aims to simulate mhc molecular structure with the hands and make a profound impression on the students.

This study investigated the conversion of monohydrocalcite (MHC) to anhydrous calcium carbonate. The primary material, MHC, was produced from waste brines containing Ca and Mg ions, reacted with sodium carbonate, which may serve in carbon capture mineralisation approach. Two different approaches were studied: 1) MHC carbonates air (under ambient conditions); 2) identification conditions could b...

Aim : A recent mental health in sport consensus statement advocates Keyes’ two continua model with an associated Mental Health Continuum (MHC) instrument to assess athletes. However, there remains statistically inconsistent usage of the MHC athletes, so further exploration MHC’s psychometric factors is required. Methods Athletes ( N = 1,097) aged 32.63 SD 11.16) comprising 603 females (55.7%) a...

To survive organisms must defend themselves against pathogens. Classical Major Histocompatibility Complex (MHC) genes play a key role in pathogen defense by encoding molecules involved recognition. MHC gene diversity influences the variety of pathogens individuals can recognize and respond to has consequently been popular genetic marker for disease resistance ecology evolution. However, is pred...

T-cell vaccination may prevent or treat cancer and infectious diseases, but further progress is required to increase clinical efficacy. Step-by-step improvements of T-cell vaccination in phase I/II clinical studies combined with very detailed analysis of T-cell responses at the single cell level are the strategy of choice for the identification of the most promising vaccine candidates for testi...

major histocompatibility complex (mhc) class ii deficiency is a primary immunodeficiency disease characterized by abnormality of mhc class ii molecules surface expression on peripheral blood lymphocytes and monocytes. clinical manifestations include extreme susceptibility to viral, bacterial, and fungal infections but the immunodeficiency is not as severe as scid (severe combined immunodeficien...