نتایج جستجو برای: mgxni1 xo

تعداد نتایج: 1552  

2006
Barbara C. Pence John J. Reiners

Topical application of the tumor promoter 12-0-tetradecanoylphorbol13-acetate (TPA) to SENCAR mouse skin results within 48 h in a 3-fold elevation of xanthine oxidase (XO) activity, an enzyme capable of gen erating the reactive oxygen species Superoxide and hydrogen peroxide. The antiinflammatory steroid fluocinolone acetonide, an inhibitor of TPAinduced hyperplasia, as well as the multiple sta...

2017
Hae In Lee Byung Rim Park Sang Woo Chun

The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) receives direct inputs from small diameter primary afferent fibers that predominantly transmit nociceptive information in the orofacial region. Recent studies indicate that reactive oxygen species (ROS) is involved in persistent pain, primarily through spinal mechanisms. In this study, we aimed to investigate th...

2002
Ron Ben Abraham Menachem Matza Sylvia Marmor Valery Rudick Inna Frolkis Itzhak Shapira Avi A. Weinbroum

Objective: Animal myocardial dysfunction induced by remote ischemia-reperfusion (IR) was shown to be partly accomplished via a direct effect of the pro-oxidant xanthine oxidase (XO). This direct remote effect was not tested in humans. We now assessed the performance of human auricles in the presence of solutions containing XO and/or allopurinol and compared them to those of rat myocardial strip...

2012
Chrysoula Spanou Aristidis S. Veskoukis Thalia Kerasioti Maria Kontou Apostolos Angelis Nektarios Aligiannis Alexios-Leandros Skaltsounis Dimitrios Kouretas

Legumes and the polyphenolic compounds present in them have gained a lot of interest due to their beneficial health implications. Dietary polyphenolic compounds, especially flavonoids, exert antioxidant properties and are potent inhibitors of xanthine oxidase (XO) activity. XO is the main contributor of free radicals during exercise but it is also involved in pathogenesis of several diseases su...

2016
Ying Qian Zhang Shun Ying Hu Yun Dai Chen Ming Zhou Guo Shan Wang

Vascular endothelial cells (ECs) appear to be one of the primary targets of hypoxia/reoxygenation (H/R) injury. In our previous study, we demonstrated that hepatocyte growth factor (HGF) exhibited a protective effect in cardiac microvascular endothelial cells (CMECs) subjected to H/R by inhibiting xanthine oxidase (XO) by reducing the cytosolic Ca2+ concentration increased in response to H/R. T...

Journal: :Cancer research 1992
D L Gustafson C A Pritsos

These studies examined the effect of dicumarol on xanthine dehydrogenase (XDH), an enzyme recently shown to bioreduce mitomycin C. Dicumarol, which has previously been shown to inhibit xanthine oxidase (XO), inhibited both XDH and XO mediated conversion of xanthine to uric acid but potentiated the metabolism of mitomycin C by XDH and XO. Formation of 2,7-diaminomitosene following mitomycin C bi...

Journal: :American journal of respiratory and critical care medicine 1998
P M Hassoun F S Yu C G Cote J J Zulueta R Sawhney K A Skinner H B Skinner D A Parks J J Lanzillo

LPS and selected cytokines upregulate xanthine dehydrogenase/xanthine oxidase (XDH/XO) in cellular systems. However, the effect of these factors on in vivo XDH/XO expression, and their contribution to lung injury, are poorly understood. Rats were exposed to normoxia or hypoxia for 24 h after treatment with LPS (1 mg/kg) and IL-1beta (100 microg/kg) or sterile saline. Lungs were then harvested f...

Journal: :Transplantation proceedings 1993
I Hamamoto S Zhang K Kokudo S Todo T E Starzl

THE XANTHINE-OXIDASE (XO) system has been considered to be involved in warm ischemia-reperfusion injury of the small intestinal mucosa. 1 Briefly, during warm ischemia in the small intestine. xanthine dehydrogenase (XD) is converted to XO, which produces superoxide radicals in the presence of its" substrate (hypoxanthine and xanthine) and oxygen.2 Meanwhile, adenosine triphosphate (ATP) is degr...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
J Scott McNally Archana Saxena Hua Cai Sergey Dikalov David G Harrison

OBJECTIVE We have previously demonstrated that endothelial xanthine oxidase (XO) levels are dependent on the NADPH oxidase. We postulated that H2O2 may modulate the irreversible conversion of xanthine dehydrogenase (XDH) to XO and sought to examine mechanisms involved. METHODS AND RESULTS H2O2 (100 micromol/L) decreased bovine aortic endothelial cell (BAEC) XDH protein expression, and metabol...

Journal: :Genetics 1983
S M Gartler M Rivest

The steroid sulfatase (STS) levels in mature oocytes of XX and XO mice were assayed along with lactate dehydrogenase (LDH), an autosomal marker, and glucose-6-phosphate dehydrogenase (G6PD), a known X-linked gene. LDH levels in XX and XO oocytes were equal, whereas STS and G6PD levels were approximately twice as high in XX oocytes as in XO oocytes. These results indicate that the STS gene is X-...

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