Marfan syndrome (MFS) is a dominantly inherited connective tissue disorder caused by mutations in the gene encoding fibrillin-1 (FBN1) and is characterized by aortic dilatation and dissection, which is the primary cause of death in untreated MFS patients. However, disease progression-associated changes in gene expression in the aortic lesions of MFS patients remained unknown. Using a mouse mode...

BACKGROUND inpatient falls are an important safety challenge, with around half causing physical injuries that compromise the recovery of older, frailer patients. Falls risk scores are in widespread use, but validation studies of their predictive values are few. OBJECTIVES to assess the predictive values of the Morse falls score (MFS) in an acute general hospital. METHODS age, admitting spec...

Results Korean MFS patients had similar height and weight compared with the general population at birth. However, linear growth curve of Korean MFS after two years of age showed that the 50th percentile of MFS is above the 97th percentile of normal in both genders. Regarding body mass, although the mean body weight of MFS patients was larger than that of the general population in males and fema...

To examine whether mossy fibers (MFs) in the cerebellar hemisphere show delay activity, we recorded MF activity during a wrist movement task with a random instructed delay period in two monkeys. Among 155 task-related MFs, 70 MFs (45%) demonstrated significant delay activity. Those MFs were widely distributed in the cerebellar hemisphere. Some of the activities were evoked by instruction cue pr...

BACKGROUND Prevention of aortic dissection and sudden death in patients with Marfan syndrome (MFS) requires accurate diagnosis. MFS is diagnosed by the Ghent criteria, which are primarily based on clinical features of Caucasian MFS populations. We determined whether the Ghent criteria apply to Asian MFS populations. METHODS AND RESULTS In this multicenter study, we included 255 adult MFS pati...

Introduction: Mothers do not recognize when their child is overweight or obese (OW-OB), and the evidence suggests a relationship between inadequate maternal perception of her child weight (MPCW), and maternal feeding style (MFS). Objectives: a) To assess the reliability of the Caregiver Feeding Style Questionnaire (CFSQ); b) to verify association between MPCW and child’ nutritional status; c) t...

BACKGROUND Extracellular matrix remodeling in the aortic wall results in increased aortic stiffness (AoS) in Marfan syndrome (MFS). Pulsed-wave velocity (PWV) constitutes the best indirect AoS measurement. We aimed to assess PWV in MFS patients using two-dimensional (2D) and Doppler echocardiography. METHODS Thirty-one MFS patients, (mean age 31 ± 14 years, 16 men) and 31 controls were examin...

During the procedure of fuzzy modeling, we use various methods to update the parameters of membership functions and the shapes of MFs change during the training procedure. So it is obvious that the shape and the distribution of MFs (not a single MF) must implicate some kinds of knowledge of target function (the function to fit) or the problem we try to model. This paper introduced the entropy E...

Fee-based membership free shipping is an important shipping fee schedule in E-Commerce. This paper studies how the membership free shipping (MFS) program affects firm competition and how to set the membership fee optimally. We find MFS relaxes price competition. The firm that adopts MFS has a higher pricing band than the other firm. Both firms have positive profits, strictly better than when me...