Developmental variations in the cranial vault arise during early ontogenesis due to premature or delayed suture closure, non-union between normal ossification centers, and emergence of additional centers. These cause abnormal calvarial partition are often associated with modifications overall configuration. This study aims evaluate impact metopic persistence development supernumerary bones occi...

BACKGROUND The premature fusion of one cranial suture, also referred to as non-syndromic craniosynostosis, most commonly involves premature fusion of the sagittal, coronal, or metopic sutures, in that order. Population-based epidemiological studies have found that the birth prevalence of single-suture craniosynostosis is both suture- and sex-dependent. METHODS Transcriptomic data from 199 ind...

Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder with polydactyly and syndactyly of the limbs and a broad spectrum of craniofacial abnormalities. Craniosynostosis of the metopic suture (interfrontal suture in mice) is an important but rare feature associated with GCPS. GCPS is caused by mutations in the transcription factor GLI3, which regulates Hedgehog signaling. ...

Metopic synostosis is characterized by keel-shaped forehead (trigonocephaly), prominent midline ridge of the forehead, bitemporal narrowing, bilateral retrusion of supraorbits, egg-shaped orbits, low nasal dorsum, and reduced volume of the anterior cranial fossa. The mainstay treatment is early surgical intervention before the age of 12 months, which usually consists of bifrontal craniotomy wit...

conclusions in the determination via 3d cranial tomography the presence of the parietal bones is important because, in case of agenesis the tension band does not benefit and on the contrary it creates extra stress on cerebral tissue. case report we presented a case with metopic and sagitta suture cranioschisis mimicking bilateral parietal bone agenesis (university of izmir of medicine, turkey, ...

In a case of congenital absence of the nose, spiral axial CT showed a tiny piriform anterior aperture on the right that ended blindly. Three-dimensional reformation of CT data showed an atretic bony plate, blind-ending right nostril, absent nasal bones, and inferior continuation of the metopic suture. Noncontrast MR findings in the brain were normal.