OBJECTIVE To compare the effects of promethazine with those of metoclopramide for hyperemesis gravidarum. METHODS Women at their first hospitalization for hyperemesis gravidarum were approached when intravenous antiemetic therapy was needed. They were randomly assigned to receive 25 mg promethazine or 10 mg metoclopramide every 8 hours for 24 hours in a double-blind study. Primary outcomes we...

The effects of atropine and metoclopramide on the lower oesophageal sphincter pressure (LOSP) were studied in 12 healthy volunteers using oesophageal pressure transducers. Atropine decreased LOSP significantly at 5 min after i.v. injection (P less than 0.005) and this change was sustained for 60 min. Metoclopramide increased LOSP significantly at 3 min after administration i.v. (P less than 0.0...

The objective of this research work is to solve the problem due iron deficiency in soybean crop. Iron chlorosis a widespread agricultural crop, especially alkaline and calcareous soils resulting complete crop failure. To eradicate problem, methodology adopted was conducted with factorial experimental design different doses (0, 2.5, 5 7.5 mgkg-1) FeDTPA 15 types soil categorized into low (L1-L5)...

Regulatory agencies in North America and Europe recently re-evaluated the safety of metoclopramide. This re-evaluation resulted in recommendations and restrictions in order to minimise the risk of neurological and other adverse reactions associated with the use of metoclopramide. In the ICU, off-label prescription of metoclopramide is common. We have reviewed the evidence for safety, effectiven...

postoperative nausea and vomiting (ponv) are one of the most common complications of anesthesia and without prophylactic intervention occurs by about one-third of patients under general anesthesia. the aim of this study was to compare the efficacy of ondansetron and metoclopramide in reducing ponv after laparoscopic cholecystectomy. in this study, 60 patients undergoing laparoscopic cholecystec...

BACKGROUND & OBJECTIVES Nausea and vomiting remain the most distressing side effects of cancer chemotherapy. The present study aimed to study the efficacy and tolerability of ondansetron versus (vs) metoclopramide in different dose related grades of cisplatin induced acute emesis. METHODS A total of 137 patients were enrolled and 80 completed the study. Cisplatin 60 mg/m2 was given intravenou...

BACKGROUND Chemotherapy- induced nausea and vomiting (CINV) occur frequently causing problems with an unacceptably high incidence that significantly affect patients' daily functioning and health-related quality of life. The present study was aimed to compare acute CINV for granisetron as 5-HT3 receptor antagonist and metoclopramide in the patients receiving chemotherapeutic regimens including c...

BACKGROUND Metoclopramide use is associated with serious and potentially irreversible neurologic side effects. However, it is often used for questionable or unclear indications in clinical practice. OBJECTIVES To (1) determine whether an intervention targeted at the prescribing physician would increase the rate of metoclopramide discontinuation among patients prescribed the medication for que...

BACKGROUND The prophylactic use of 5-HT(3) receptor antagonists (setrons), after the first 24 h (acute phase) of exposure to emetic chemotherapy, to decrease the incidence of 'delayed phase' emesis increases costs. We designed a study to evaluate the efficacy of a setron (granisetron) in the delayed phase, compared with metoclopramide, each combined with a corticosteroid. PATIENTS AND METHODS...