High-dose intravenous methylprednisolone therapy has previously been shown to be efficacious in the treatment of renal lupus erythematosus. The present report presents 2 patients with life-threatening, nonrenal lupus erythematosus. One patient had coma and seizures, while the other had sever thrombocytopenia and anaemia. Both had failed to respond to oral corticosteroid therapy in high doses bu...

conclusions kd should be kept in mind as one of the causes of childhood acalculous cholestasis, abdominal discomfort and prolonged fever. case presentation we report a four-year-old boy with fever, abdominal pain, vomiting, jaundice and mild liver enlargement who gradually developed other signs of kd. he was treated by aspirin, intravenous immunoglobulin and finally methylprednisolone pulse the...

Three patients with refractory rheumatoid arthritis were treated with oral cyclophosphamide; in two cases this was supplemented with pulse treatment with methylprednisolone. Long term remission was induced in all three patients and was sustained until follow up at least nine months after the methylprednisolone was stopped. Leucopenia occurred but resolved when cyclophosphamide was reduced from ...

and the penetrance is highly variable. It has been suggested that a ‘‘second hit’’ is required to precipitate the phenotype and could cause further deregulation of BMPR2/Smad signalling, leading to PAH [9, 10]. Although the significance of gremlin levels in PAH has yet to be determined, in a mutation carrier developing IPF, hypoxia or increased gremlin levels may account for a second insult, le...

We present a young Thai man who developed acute flaccid paralysis after receiving pulse methylprednisolone for chronic inflammatory demyelinating polyneuropathy. Hypokalemia from intracellular shift was confirmed by calculation of transtubular potassium gradient (TTKG). His muscle strength and serum potassium fully recovered with a small amount of potassium replacement. Graves' disease was subs...

372 14. Lin JL, Lin-tan DT, Chen KH, et al. Repeat pulse of methylprednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning. Crit Care Med 2006; 34(2): 368-373. 15. Lin NC, Lin JL, Lin-Tan DT. Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure. J Toxicol Cli...