Methemoglobinemia is a life-threatening condition that can be difficult to diagnose. While methemoglobinemia can be congenital and should be considered in cyanotic infants,1 it is more often an adverse medication effect, most commonly related to dapsone use.2 As up to 1 in 9 emergency department visits in Canada might be owing to adverse medication effects, physicians and other health care prov...

BACKGROUND Methemoglobinemia due to the administration of sulfamethoxazole/trimethoprim has been documented in a series of case reports. However, all of these reports are on adult patients, and all patients received at least daily administration of sulfamethoxazole/trimethoprim for the treatment of active or suspected infection. CASE REPORT Herein we report the development of methemoglobinemia ...

Methemoglobinemia, one of the rare causes of cyanosis and hypoxemia, may occur in congenital and acquired forms. Coexistence of cyanosis and hypoxemia suggests an etiology associated with an underlying cardiac disease firstly, but if any cardiac pathology exists pulmonary diseases are investigated generally. Considering bronchial asthma in a young patient with shortness of breath is usual. On t...

We herein report a case of methemoglobinemia induced by trimethoprim-sulfamethoxazole (TMP/SMX). A 41-year-old woman with systemic lupus erythematosus (SLE) received TMP/SMX for prophylaxis of pneumocystis pneumonia (PCP) on the 7th day of hospitalization. She suddenly developed dyspnea and cyanosis on the 9th day of hospitalization. The level of oxygen saturation (SaO2) decreased, and the conc...

parents and sibling Fourthly, there was no family history suggestive of methemoglobinemia and methemoglobrn levels of both the parents and elder sibling were normal Fifthly, There is transient physiologic deficiency of cytochrome b5 reductive activity in neonates approximately 60% of the normal adult value, and even greater reduction in premature neonates is known making them more susceptible t...

Methemoglobinemia is life-threatening and bears pathognomonic signs difficult to diagnose in real time. Local anesthetics are widely used and are known for eliciting this condition. We report a case of methemoglobinemia secondary to self-administered use of benzocaine spray. A 27-year-old woman was found to be in respiratory distress during postoperative recovery. After desaturation persisted, ...

BACKGROUND In veterinary medicine, congenital methemoglobinemia associated with nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase (b5R) deficiency is rare. It has been reported in several breeds of dogs, but little information is available about its etiology. OBJECTIVES To analyze the NADH-cytochrome b5 reductase gene, CYB5R3, in a Pomeranian dog family with methemoglobinemia s...

Methemoglobinemia is a potential negative side effect associated with the use of benzocaine for topical anesthesia. A healthy patient admitted for an outpatient orthopedic procedure developed the clinical symptomatology of methemoglobinemia after topicalization of the airway with benzocaine. The patient subsequently responded to appropriate treatment and was fit for discharge the same day. Meth...

Methemoglobinemia is a disorder characterized by the presence of a higher than normal level of methemoglobin. Prilocaine which is one of the oxidizing local anaesthetics is widely used in many local procedures. The first choice of treatment of complications due to the use of these local anaesthetics is methylene blue, while ascorbic acid is the alternative choice. The side effects of metilen bl...