Localized proton magnetic resonance spectroscopy (H MRS) became an important tool for investigating brain metabolism non-invasively. In animal models, high field H MRS allows detection of almost 20 metabolites [1-4], also called the neurochemical profile (taurine (Tau), creatine (Cr), phosphocreatine (PCr), phosphocholine (PCho), glycerophosphocholine (GPC), glutamate (Glu), glutamine (Gln), my...

this study was conducted to determine the effect of dietary turmeric rhizome powder (trp) as a natural antioxidant, and soybean oil, canola oil and tallow on lipid metabolism, blood metabolites, immune system, and antioxidant status of broiler chickens before (bhs, 28 d) and after exposure to heat stress (ahs, 42 d). seven hundred and ninety two d-old male arian broilers were randomly allotted ...

Identifying the association between metabolites and diseases will help us understand pathogenesis of diseases, which has great significance in diagnosing treating diseases. However, traditional biometric methods are time consuming expensive. Accordingly, we propose a new metabolite-disease prediction algorithm based on DeepWalk random forest (DWRF), consists following key steps: First, semantic...

the lack of authentic standards has limited the quantitative analysis of herbal drugs in biological samples. the present work demonstrated a practicable strategy for the assay of herbs and their metabolites independent of authentic standards. a liquid chromatography–electrospray ionization–mass spectrometry (lc–esi–ms) method for the qualitative and quantitative determination of the metabolites...

Acebutolol (AC) is a chiral b-adrenergic blocking drug, which is useful clinically as the racemate in treating hypertension and is metabolized to an equipotent chiral metabolite, diacetolol (DC). In this paper we report a case of a 32 year old woman who was receiving AC during her pregnancy and lactating time for management of hypertension. The maternal plasma level and breast milk as well as c...

Acebutolol (AC) is a chiral b-adrenergic blocking drug, which is useful clinically as the racemate in treating hypertension and is metabolized to an equipotent chiral metabolite, diacetolol (DC). In this paper we report a case of a 32 year old woman who was receiving AC during her pregnancy and lactating time for management of hypertension. The maternal plasma level and breast milk as well as c...

While the entirety of 'Chemical Space' is huge (and assumed to contain between 10(63) and 10(200) 'small molecules'), distinct subsets of this space can nonetheless be defined according to certain structural parameters. An example of such a subspace is the chemical space spanned by endogenous metabolites, defined as 'naturally occurring' products of an organisms' metabolism. In order to underst...