Evaluation of calcified metastatic lesions by conventional imaging can be challenging. Ovarian cancer metastases can present with calcification which might increase in size and number following therapy. It is not entirely clear whether these calcifications are associated with tumor response or disease progression. Calcified lesions which do not change in size or configuration are particularly p...

Consequences of directional selection on metabolic flux are explored in models for which variation in flux among individuals is generated by segregation of allelic variants at enzyme activity loci. The pattern of selection response is strongly affected by the presence of genetic dominance and epistasis, which are automatically generated in metabolic systems. The expected magnitudes of dominance...

Since Cuthbertson first published his important investigations, the metabolic response to trauma has been the subject of continuous study in many disciplines of medicine (1-8). An impressive body of knowledge has been accumulated with respect to changes in plasma electrolyte concentrations, urinary electrolyte excretion, body composition, and adrenocortical activity. There is general agreement ...

The syndrome of cachexia is characterized by anorexia and profound losses of host tissues and constitutes one of the most common paraneoplastic conditions seen with cancer. Furthermore, cachexia is associated with a considerable mortality and morbidity but its origin is still obscure and cachexia remains a multi-factorial problem. A better understanding of the cause of the cachectic process and...

conclusions adherence to the meddiet, according to mds and sofi-mds, may not predict mets components and mets incidence after 3 years of follow-up in iranian adult populations. results after adjusting for potential confounders, neither higher mds nor higher sofi-mds were significantly associated with the mean values of mets components and the risk of metabolic abnormalities incidence after 3 ye...