Hysteretic enzymes are defined as those enzymes which respond slowly (in terms of some kinetic characteristic) to a rapid change in ligand, either substrate or modifier, concentration. Such slow changes, defined in terms of their rate relative to the over-all catalytic reaction, result in a lag in the response of the enzyme to changes in the ligaml level. Several mechanisms, including ligand-in...

MOTIVATION One of the challenging questions in modelling biological systems is to characterize the functional forms of the processes that control and orchestrate molecular and cellular phenotypes. Recently proposed methods for the analysis of metabolic pathways, for example, dynamic flux estimation, can only provide estimates of the underlying fluxes at discrete time points but fail to capture ...

genome. Experiments performed to determine relationships between these parameters in various nutrient media are described and interpreted. After discussing steady states, attention is focused upon the very interesting work on variation of synthesis rates when bacteria are transferred from a minimal to an enriched medium. Measurement of the rates for various classes of macromolecules reveals tha...

Thermodynamic constraints are essential for understanding the behaviour of living systems, but they are far from sufficient, because they allow a wide range of possibilities. Additional constraints imposed by kinetic considerations are often crucial in determining not merely whether a process can occur, but whether it does. Entropies of activation are in principle very useful for analysing expe...

glycosidases are the enzymes involved in various biochemical processes related to metabolic disorders and diseases. therefore, much effort has been focused on searching novel pharmacotherapy for the treatment of these ailments from medicinal plants due to higher safety margins. to pursue these efforts, the present study was performed to evaluate the α-glucosidase inhibitory activities of thirty...