BACKGROUND Delayed hypersensitivity plays a large role in the pathogenesis of tuberculous pleural effusion (TPE). Macrophages infected with live Mycobacterium tuberculosis (MTB) increase the levels of adenosine deaminase2 (ADA2) in the pleural fluid of TPE patients. However, it is as yet unclear whether ADA2 can be produced by macrophages when challenged with MTB antigens alone. This study ther...

This study investigates the use of discourse markers by Spanish learners of English. It is intended as an initial contribution to the study of how discourse markers are used by foreign language learners. We conduct two pilot studies involving the use of English discourse markers by native speakers of Spanish. We first study if these speakers use English discourse markers at all in their writing...

Text complexity can be reduced by making different choices at the lexical and grammatical levels. However, discourse-level choices may also affect a text’s complexity. In a coherent text, explicit discourse relations (e.g. CAUSE, CONDITION) are expressed using discourse markers (e.g. since, because, etc.) that may be preferred for texts at different readability levels. In this paper, we investi...

Discourse markers, also known as clue words, are used extensively in human-human task-oriented dialogs to signal the structure of the discourse. Previous work showed their importance in monologs and social conversations for marking discourse structure , but little attention has been paid to their importance in spoken dialog systems. This paper investigates what discourse markers signal about th...

A spontaneously spoken, natural Japanese discourse contains many instances of the so-called redundant interjections and of back-channel utterances. These expressions have not hitherto received much attention and few systematic analyses have been made, since they were regarded as useless, spurious expressions. On the basis of the analysis of spoken dialogue corpus, we claim that these utterances...

Porcine reproductive and respiratory syndrome (PRRS) is one of the most significant and economically important infectious diseases affecting swine worldwide and can predispose pigs to secondary bacterial infections caused by, e.g. Haemophilus parasuis. The aim of the presented study was to compare susceptibility of two different types of macrophages which could be in contact with both pathogens...

Tissue infiltration of macrophages, although critical for innate immunity, is also involved in pathologies, such as chronic inflammation and cancer. In vivo, macrophages migrate mostly in a constrained three-dimensional (3D) environment. However, in vitro studies, mainly focused on two dimensions, do not provide meaningful clues about the mechanisms involved in 3D macrophage migration. In contr...

BACKGROUND Type 2 diabetes (T2D) is a risk factor for the development of tuberculosis (TB), although the associated mechanisms are not known. OBJECTIVES To study the association between T2D and the basal phenotype of macrophages, and their immune response to Mycobacterium tuberculosis (Mtb) infection. METHODS We evaluated the influence of T2D on the response of monocyte-derived macrophages ...

Discourse markers are complex discontinuous linguistic expressions which are used to explicitly signal the discourse structure of a text. This paper describes efforts to improve an automatic tagging system which identifies and classifies discourse markers in Chinese texts by applying machine learning (ML) to the disambiguation of discourse markers, as an integral part of automatic text summariz...