The ability to antagonise c-MET oncogene activity with agents affecting the interaction Met tail/SH2-containing transducer Grb2, is expected to result in inhibition of both metastatic invasion and proliferation. The goal of this study was to establish a discovery strategy to identify small organic molecules as antagonists of Met oncogene activity in primary and metastatic tumors by inhibition o...

Cell culture, tissue chemistry and flow cytometry were used to determine whether antisense c-Met oligodeoxynucleotides enhanced the sensitivity of human glioma cells to paclitaxel. A combination of paclitaxel with antisense c-Met oligodeoxynucleotides inhibited cell growth, induced apoptosis and induced c-Met protein expression in U251 and SHG44 human glioma cells more significantly than either...

BACKGROUND Previously, we identified a sequence variant (N375S) of c-Met gene, however, its association with lung cancer risk and prognosis remain undefined. PATIENTS AND METHODS We investigated the genotype distribution of the c-Met-N375S sequence variant in 206 lung cancer patients and 207 non-cancer controls in the Taiwanese population by DNA sequencing. RESULTS Lung cancer patients with...

ownloade kground: Estimates of human papillomavirus (HPV) concordance among sexual partners are imporr various public health activities, from counseling individual patients to predicting the effect of HPV ation. thods:We systematically searched the PubMed and EMBASE databases for studies of HPV concordance heterosexual couples published through 2008 in English. Two coders independently abstract...

BACKGROUND: The degree to which the amount of aningested nutrient is absorbed and available to the body is calledbioavailability. OBJECTIVES: Relative effectiveness of herbalmethionine (H-Met®) compared to DL-methionine (DL-Met)was investigated in this experiment. METHODS: Exponentialregression analysis was used to determine bioefficacy of H-Met®based on body weight gain, feed intake and feed c...

background:herbal methionine can be compared relative todl-methionine with evaluation of bioavailability of this source ofmethionine. objectives: an experiment was carried out todetermine the relative bioefficacy of herbal methionine (h-met)®relative to dl-methionine (dl-met) on performance criteria andimmunocompetence of met sources in male broilers. atotal of 160male broilers were fed a met-d...