Objective: Mesobuthus tumulus is the most lethal among all poisonous species of scorpion. Aristolochia indica is one of the plants which have long been used in traditional herbal medicine for the treatment of poisoning by animal bites. Hence the study was planned to evaluate the ethanolic extract of Aristolochia indica for the treatment of Mesobuthus tamulus envenoming. Materials and Methods: C...

The venoms of Buthidae scorpions are known to contain basic, single-chain protein -toxins consisting of 60-70 amino acid residues that are tightly cross-linked by four disulfide bridges. Total RNA was extracted from the venom glands of scorpion Mesobuthus eupeus collected from the Khuzestan province of Iran and then cDNA was synthesized with the modified oligo (dT) primer and extracted total R...

Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. Mesobuthus eupeus, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyz...

This brief review summarizes the studies in systematics and zoogeography of European scorpions. The current “splitting” trend in scorpion taxonomy is only a reasonable response to the former “lumping.” Our better understanding of scorpion systematics became possible due to the availability of new morphological characters and molecular techniques, as well as of new material. Many taxa and local ...

this study aimed to evaluate the clinical, histopathological and hematological effects of mesobuthus eupeus venom on chicken organs. adult chickens were subcutaneously injected with five doses of m. eupeus venom (0.5, 2, 5, 10 and 20 mg/kg; four chickens per each dose). symptoms were recorded during the experiment and blood samples were collected for hematological analysis. moreover, a complete...

introduction: scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (amps) have been found in the venom gland of scorpions. therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. here, we describe three new cationic amps, including meuvap-6, meuap-18-1, and meupep34 from the ve...

BACKGROUND Scorpion venom is important and rich source of peptides, most of which have been widely used as pharmacological tools for unraveling structure-function relationship of various ion channels. Naturally occurring toxins can be also considered as lead compounds in the development of novel drugs. OBJECTIVES In this context, the scorpion-derived peptide neurotoxins specific to sodium cha...