The mitochondrial genome of Trypanosoma brucei, called kinetoplast DNA, is a network of topologically interlocked DNA rings including several thousand minicircles and a few dozen maxicircles. Kinetoplast DNA synthesis involves release of minicircles from the network, replication of the free minicircles and reattachment of the progeny. Here we report a new function of the mitochondrial topoisome...

One potential cause for concern, and an inherent weakness with the naïve matching methodology described in the paper, is that the method considers only the year, industry, and funding reception on the part of the entrepreneur. To the extent that structural components of the VC syndicate (i.e., size and relative reputation), or observable characteristics of the entrepreneur, may correlate with t...

This article immerses the reader into world of garment mending in communal repair events four cities— Helsinki, Auckland, Wellington, and Edinburgh—to explore as a locus taste. It engages discussion on taste reflexive activity sensed effect that gradually reveals itself to practitioners engaged practice mending. Here focus is role body interplay between sensing materials, show how everyday mend...

More people die every year from ischemic heart disease than any other disease. Because the human heart lacks sufficient ability to replenish the damaged cardiac muscles, extensive research has been devoted toward understanding the homeostatic and regenerative potential of the heart and to develop regenerative therapies for heart disease. Here, we discuss recent advances in the understanding of ...

Recent studies have elucidated the activation mechanism of the Rad53 checkpoint kinase and the role of Rad9-like adaptor proteins in mediating signal transduction from PIKK sensor kinases that detect DNA damage to the effector kinases that play a part in mending that damage.

American Indians and Alaska Natives are vulnerable populations with significant levels of trauma exposure. The Indian Country Child Trauma Center developed an American Indian and Alaska Native (AI/AN) adaptation of the evidence-based child trauma treatment, trauma-focused cognitive-behavioral therapy. Honoring Children, Mending the Circle (HC-MC) guides the therapeutic process through a blendin...