Membrane contact sites (MCS) are regions of close apposition between membrane-bound organelles. Proteins that occupy MCS display various domain organisation. Among them, lipid transfer proteins (LTPs) frequently contain both structured domains as well intrinsic disorder. In this review, we discuss the roles intrinsically disordered protein (IDPRs) in LTPs other associated with organelle sites. ...

A significant part of the membrane protein surface is stably exposed to hydrophobiccore lipid bilayers rather than aqueous environment. Surprisingly, this importinformation rarely considered for structure predictions. Here we propose anew property, namely ‘Lipid Contact Probability’ or LCP short, explicitlydescribe likelihood an amino acid a given sequence in direct contact with thehydrophobic ...

Transport proteins are essential for cells in allowing the exchange of substances between and their environment across lipid bilayer forming a tight barrier. Membrane lipids modulate function transmembrane such as transporters two ways: Lipids tightly specifically bound to transport addition they from bulk proteins. This overview summarizes currently available information at ultrastructural lev...

The OPM (Orientation of Proteins in Membranes) database currently holds, classifies, and annotates around 14,000 three-dimensional structures transmembrane peripheral membrane proteins peptides positioned with respect to boundaries. Developing uniform templates biological membranes realistic native-like lipid composition would provide a convenient accurate platform for researchers who simulate ...

Life relies on the constant exchange of different forms energy, i.e., energy transduction. Therefore, organisms have evolved in a way to be able harvest made available by external sources (such as light or chemical compounds) and convert these into biological useable forms, such transmembrane difference electrochemical potential (???). Membrane proteins contribute establishment ??? coupling exe...

Medicinal plants exerted their antibacterial effects through many mechanisms included inhibition of cell wall synthesis, membrane disruption cytoplasmic membrane, bacterial proteins nucleic acid energy metabolism, as well virulence factors. The current review highlighted the medicinal with activity spectrum action.