Probenecid by inhibiting the renal excretion of penicillin raises its serum level (Boger, Beatty, Pitts, and Flippin, 1950; Burnell and Kirby, 1951; Meads, Knight, and Izlar, 1951; Frisk, Diding, and Wallmark, 1952), a pharmacological effect of which increasing use has been made in the treatment of gonorrhoea (Hilton, 1959; Jensen, Kvorning, and N0rredam, 1963; Holmes, Johnson, and Floyd, 1967;...

Introduction. One commonly used method for in-vivo magnetic resonance spectroscopy (MRS) detection of γ-aminobutyric acid (GABA) is the MEGA-PRESS technique [1], which enables direct observation of the GABA resonance at 3.02 ppm. Unfortunately, direct quantification of GABA using MEGA-PRESS is complicated by co-editing of macromolecule (MM) signals, which also resonate at 3.02 ppm [2]. Two meth...

background: in conventional radiation therapy, regarding normal tissue tolerance, the treatment of bulk tumors is one of the remaining challenges. grid radiation therapy (grt) is a technique to deliver high doses, approximately 15 – 20 gy per fraction, to several small volumes located in a large radiation field. this can be performed using a grid block. the current work has concentrated on the ...

Efflux-mediated macrolide resistance due to mef(E) and mel, carried by the mega element, is common in Streptococcus pneumoniae, for which it was originally characterized, but it is rare in Streptococcus pyogenes In S. pyogenes, mega was previously found to be enclosed in Tn2009, a composite genetic element of the Tn916 family containing tet(M) and conferring erythromycin and tetracycline resist...

The dilatations that occur in the body are classified according to different systems: (1) biliary: mega-gallbladder, mega-common bile duct; (2) cardiovascular: cardiomegaly; (3) urinary: megapelvis, megaureter, megabladder; (4) respiratory: bronchiectasis, megabronchus; (5) megapharynx (?); (6) megaesophagus; (7) megastomach; (8) achalasia of the pylorus or hypertrophic pyloric stenosis; (9) me...

The MEGA microlensing survey is introduced and several topics about variable stars in M31 are discussed. An adopted model population of semiregular (SR) variable stars is presented, and the efficiency to recover these stars in M31 in a specific example MEGA dataset is predicted. The period-flux amplitude relation of the SRs discovered by MEGA could be used to measure the inclination of the M31 ...

Recently it has become apparent that there is a tendency for penicillin to fail in the treatment of gonorrhoea (Curtis and Wilkinson, 1958; King, 1958; Willcox, 1959). This would appear to be due to the development of resistance on the part of the gonococcus. It was decided to compare the effect in vivo of two new antibiotics using two series treated with penicillin as controls. In one control ...

385 Aneurysmal dilation of AVF is due to the complex interplay between biologic factors like needle injury that induce outward wall remodeling, and physical factors such as wall tension that is directly proportional to intraaccess pressures. In a series of patients who underwent minimally invasive limited ligation endoluminal-assisted revision banding, pressure within the mid-fistula was reduce...

γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS). In a GABA-edited MEGA-PRESS spectrum, Glu and Gln co-...