نتایج جستجو برای: mef

تعداد نتایج: 1416  

2012
Ioanna N Grivea Alexia Sourla Eleni Ntokou Denise C Chryssanthopoulou Alexandra G Tsantouli George A Syrogiannopoulos

BACKGROUND We sought to characterize the temporal trends in nasopharyngeal carriage of macrolide-resistant pneumococci during a period with increased heptavalent pneumococcal conjugate vaccine (PCV7) coverage in Central Greece. METHODS Streptococcus pneumoniae isolates were recovered from 2649 nasopharyngeal samples obtained from day-care center attendees in Central Greece during 2005-2009. A...

Journal: :The Journal of antimicrobial chemotherapy 2004
Andrea Brenciani Kayode K Ojo Alessia Monachetti Stefano Menzo Marilyn C Roberts Pietro E Varaldo Eleonora Giovanetti

OBJECTIVES To analyse the distribution and molecular features of mef(A)-containing elements in a large collection of different Streptococcus pyogenes clinical isolates with efflux-mediated erythromycin resistance. To further characterize a tet(O)-mef(A) element. METHODS Gene detection was carried out by PCR using primers designed from established sequences or from sequences in this study. Fro...

2012
Shiu-Ming Kuo Lana R. Burl Zihua Hu

Vitamin C has been shown to delay the cellular senescence and was considered a candidate for chemoprevention and cancer therapy. To understand the reported contrasting roles of vitamin C: growth-promoting in the primary cells and growth-inhibiting in cancer cells, primary mouse embryonic fibroblasts (MEF) and their isogenic spontaneously immortalized fibroblasts with unlimited cell division pot...

2012
Mari Pekkanen-Mattila Marisa Ojala Erja Kerkelä Kristiina Rajala Heli Skottman Katriina Aalto-Setälä

Mouse embryonic fibroblasts (MEFs) and human foreskin fibroblasts (hFFs) are commonly used as feeder cells to maintain the pluripotent state of stem cells. The aim of the present study was to evaluate the effect of MEF and hFF feeders on the cardiac differentiation. Two human embryonic and two induced pluripotent stem cell lines were cultured on MEF and hFF before cardiac differentiation. The e...

Journal: :The EMBO journal 1999
D B Sparrow E A Miska E Langley S Reynaud-Deonauth S Kotecha N Towers G Spohr T Kouzarides T J Mohun

The MEF-2 proteins are a family of transcriptional activators that have been detected in a wide variety of cell types. In skeletal muscle cells, MEF-2 proteins interact with members of the MyoD family of transcriptional activators to synergistically activate gene expression. Similar interactions with tissue or lineage-specific cofactors may also underlie MEF-2 function in other cell types. In o...

Journal: :The Journal of biological chemistry 2013
Koji Ando Hideki Tsushima Emi Matsuo Kensuke Horio Shinya Tominaga-Sato Daisuke Imanishi Yoshitaka Imaizumi Masako Iwanaga Hidehiro Itonaga Shinichiro Yoshida Tomoko Hata Ryozo Moriuchi Hitoshi Kiyoi Stephen Nimer Hiroyuki Mano Tomoki Naoe Masao Tomonaga Yasushi Miyazaki

Myeloid ELF1-like factor (MEF/ELF4), a member of the ETS transcription factors, can function as an oncogene in murine cancer models and is overexpressed in various human cancers. Here, we report a mechanism by which MEF/ELF4 may be activated by a common leukemia-associated mutation in the nucleophosmin gene. By using a tandem affinity purification assay, we found that MEF/ELF4 interacts with mu...

Journal: :Biophysical Journal 2009

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008
Li-Hui Wang Jing-Yu Yang Wei Cui Young Kee Shin Chun-Fu Wu

The promyelocytic leukemia (PML) gene is a tumor suppressor gene associated with cell apoptosis, cell proliferation, and senescence. However, the role of PML in the ethanol-induced apoptosis is not fully-known. In this study, using wild-type mouse embryo fibroblasts (MEF) and PML null MEF cells, we found that (1) ethanol (100 mM and 200 mM) could obviously induce apoptosis of wild-type MEF cell...

Journal: :Nusantara bioscience 2022

Moringa oleifera Lam. (Family Moringaceae) is a medium sized perennial tree, commonly known as drumstick horse raddish miracle sahjan, shobhanjana, munga arak, etc., in different languages. Leaves, flowers and pods of the plant are edible. Various parts utilized for treatment several diseases by ethnic communities, including heart ailments. Leaves M. were assessed preliminary qualitative phytoc...

Journal: :Journal of clinical microbiology 2003
Ken B Waites Kellie E Jones Kyung Hyo Kim Stephen A Moser Crystal N Johnson Susan K Hollingshead Eun-Suk Kang Ki Sook Hong William H Benjamin

Macrolide resistance was detected in 64 of 77 (83.1%) Streptococcus pneumoniae isolates from South Korea. Seven (10.9%) isolates contained only mef(A), 32 (50%) contained only erm(B), and 25 (39.1%) contained mef(A) and erm(B). Nineteen isolates containing mef(A) and erm(B) belonged to serotype 19F, and seven isolates were identical to the Taiwan(19F)-14 clone.

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