With great interest we read the article by Meeker et al. (1) on abnormalities of telomere length occurring early in the initiation of epithelial carcinogenesis. From in situ assessment of telomere length in formalin-fixed human surgical specimens of epithelial cancer precursor lesions, it was concluded that this methodology may be useful as an early biomarker for monitoring disease prevention s...

Regulatory agencies around the world have recommended reporting confidence intervals for treatment differences along with the results of significance tests. SAS provides easy and convenient ways to produce confidence intervals using procedures such as PROC GLM and PROC UNIVARIATE in conjunction with ODS (output delivery system). In this paper, I will discuss the relationship between significanc...

This is a guide to coordinate systems, representations, and geometric relationships between them, for components of the Rochester Robotics Laboratory. The main entities at issue are the joint angles, location variables, and coordinate systems of the Puma, the camera angles and coordinate systems associated with the head, the spatial location of three-dimensional points, and the kinematic and in...

Pathogens may alter their hosts, which consequently increases transmission efficiency by vectors. We examined the effects of Raspberry leaf mottle virus [RLMV; Closterovirus (Closteroviridae)] and Raspberry latent virus [RpLV; Reovirus (Reoviridae)], alone and in a co-infection in raspberry, Rubus idaeus L. (Rosaceae) cv. Meeker, on the behavior and performance of its vector, Amphorophora agath...

Formation of granuloma and production of antibodies in guinea-pigs receiving egg albumen with Freund's adjuvant may be suppressed by cortisone (Fischel, Kabat, Stoerk, Skolnick, and Bezer, 1954). The arthritis induced in rats by Freund's adjuvant may also be prevented by treatment with cortisone (e.g. Houssay and Frangione, 1961; Pearson, Wood, and Waksman, 1961), pyrazolidines, salicylates, an...

Many industrial products consist of multiple components that are necessary for system operation. There is an abundance of literature on modeling the lifetime of such components through competing risks models. During the life-cycle of a product, it is common for there to be incremental design changes to improve reliability, to reduce costs, or due to changes in availability of certain part numbe...

1 Ahuja A, Gothi D, Joshi J. A 52-year-old man with daytime sleepiness, sialorrhea, and facial fasciculations. Chest 2006; 130:287–290 2 Servera E, Sancho J. Appropriate management of respiratory problems is of utmost importance in the treatment of patients with amyotrophic lateral sclerosis [editorial]. Chest 2005; 127:1879–1882 3 Aboussouan LS, Khan SU, Meeker DP, et al. Effect of noninvasive...

To identify a post-plant nematicide to control root lesion nematode [RLN (Pratylenchus penetrans)] in red raspberry (Rubus idaeus), a number of nematicides was tested in soil-only and plant-based experiments. In soil-only experiments, soil naturally infested with RLN was drenched with the nematicides and nematode survival was assessed 7 and 14 days after treatment. Fosthiazate and oxamyl reduce...