OBJECTIVE Estro-progestin treatments have been associated with an increased risk of thromboembolic events in postmenopausal women. This study examined whether progestins affect the stimulatory effect of estrogens on the endothelial formation of nitric oxide (NO), a potent antithrombotic factor. METHODS AND RESULTS Experiments were performed with human endothelial cells. Endothelial NO synthas...

Objectives—Estro-progestin treatments have been associated with an increased risk of thromboembolic events in postmenopausal women. This study examined whether progestins affect the stimulatory effect of estrogens on the endothelial formation of nitric oxide (NO), a potent antithrombotic factor. Methods and Results—Experiments were performed with human endothelial cells. Endothelial NO synthase...

A minority of individuals with mental retardation engage in offensive sexual behavior (e.g., child molestation, genital exposure, rape). Many of these individuals may benefit from the adjunctive administration of antilibidinal drugs. The two most widely used are the antiandrogens, medroxyprogesterone acetate (MPA) and cyproterone acetate (CPA). In the present paper the efficacy, cautions, side ...

Background In 2004, WHO Pharmaceuticals Newsletter reported a Pfizer Canada advice originated by results of new clinical studies that suggest the association between use of medroxyprogesterone acetate suspension for injection and substantial loss in bone mineral density. The publication stressed: “The loss in bone density is greater with increasing duration of treatment. The loss in bone densit...

BACKGROUND AND PURPOSE Tibolone is a tissue-specific compound that has favorable effects on bone and menopausal symptoms without stimulating endometrium or breast, but lowers concentrations of plasma high-density lipoprotein (HDL) cholesterol (HDLC). This study was designed to determine whether the HDL lowering with tibolone exacerbated common or internal carotid artery atherosclerosis and to e...

Background:Medroxyprogesterone acetate (MPA) is a common contraceptive agent taken both orally and as a subcutaneous or intramuscular injection. Current LC-MS/MSmethods for MPA quantification require large sample volumes and low-throughput analytical run times. Therefore, there are opportunities to improve upon existing methods for MPA quantification. Methods: MPA was extracted from 600 μL plas...

To understand the rationale of high-dose medroxyprogesterone acetate (MPA) in the treatment of well-differentiated uterine endometrial cancers, the effect of MPA on intracellular sex hormone-binding globulin (SHBG) mRNA expression in well-differentiated uterine endometrial cancer cell line Ishikawa was determined by competitive reverse transcription-polymerase chain reaction-Southern blot analy...

Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone HRT decreases the risk of breast cancer in postmenopausal women, whereas combined estrogen plus a progestin (medroxyprogesterone acetat...

AIM To investigate if a levonorgestrel-impregnated intrauterine system (LNG-IUS) was more efficient compared to oral progestin in the clearance of the paired box 2 gene (PAX2) - and phosphatase and tensin homolog (PTEN)-null endometrial glands and assess the significance of PAX2- and PTEN-null glands as markers for therapy response in endometrial hyperplasia. PATIENTS AND METHODS Immunohistoc...